Chan, Chi-Bun

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

Zhang, Z., Liu, X., Schroeder, J. P., Chan, C.-B., Song, M., Yu, S. P., Weinshenker, D., & Ye, K. (2014) · Neuropsychopharmacology

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 242

Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome

Gross, C., Nakamoto, M., Yao, X., Chan, C.-B., Yim, S. Y., Ye, K., Warren, S. T., & Bassell, G. J. (2010) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 241

A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect

Liu, X., Chan, C.-B., Jang, S.-W., Pradoldej, S., Huang, J., He, K., Phun, L. H., France, S., Xiao, G., Jia, Y., et al. (2010) · Journal of Medicinal Chemistry

Synthesis of Organic CompoundsTreatment of Major Depression

Cited by 208

7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders

Liu, C., Chan, C. B., & Ye, K. (2016) · Translational Neurodegeneration

Nerve injury and regenerationFlavonoids in Medical Research

Cited by 195

Amitriptyline is a TrkA and TrkB Receptor Agonist that Promotes TrkA/TrkB Heterodimerization and Has Potent Neurotrophic Activity

Jang, S.-W., Liu, X., Chan, C.-B., Weinshenker, D., Hall, R. A., Xiao, G., & Ye, K. (2009) · Chemistry & Biology

Nerve injury and regenerationTreatment of Major Depression

Cited by 144

Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

Gross, C., Chang, C.-W., Kelly, S. M., Bhattacharya, A., McBride, S. M. J., Danielson, S. W., Jiang, M. Q., Chan, C. B., Ye, K., Gibson, J. R., et al. (2015) · Cell Reports

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 117

Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice

Ahuja, P., Ng, C. F., Pang, B. P. S., Chan, W. S., Tse, M. C. L., Bi, X., Kwan, H.-L. R., Brobst, D., Herlea-Pana, O., Yang, X., et al. (2022) · Autophagy

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 116

Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice

Jang, S.-W., Liu, X., Chan, C. B., France, S. A., Sayeed, I., Tang, W., Lin, X., Xiao, G., Andero, R., Chang, Q., et al. (2010) · PLoS ONE

Nerve injury and regenerationMedicinal Plants and Neuroprotection

Cited by 101

Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility

Yang, X., Brobst, D., Chan, W. S., Tse, M. C. L., Herlea-Pana, O., Ahuja, P., Bi, X., Zaw, A. M., Kwong, Z. S. W., Jia, W.-H., et al. (2019) · Science Signaling

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 99

High-fat diet-induced diabetes couples to Alzheimer’s disease through inflammation-activated C/EBPβ/AEP pathway

Liu, P., Wang, Z.-H., Kang, S. S., Liu, X., Xia, Y., Chan, C.-B., & Ye, K. (2022) · Molecular Psychiatry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 77

Optimization of a Small Tropomyosin-Related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression

Liu, X., Chan, C.-B., Qi, Q., Xiao, G., Luo, H. R., He, X., & Ye, K. (2012) · Journal of Medicinal Chemistry

Treatment of Major DepressionSynthesis of Organic Compounds

Cited by 60