Henderson, Neil C.

Fibrosis: from mechanisms to medicines

Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature

Liver physiology and pathologyInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 1,868

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., et al. (2019) · Nature

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 1,784

Differential abundance testing on single-cell data using k-nearest neighbor graphs

Dann, E., Henderson, N. C., Teichmann, S. A., Morgan, M. D., & Marioni, J. C. (2022) · Nature Biotechnology

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 938

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

Henderson, N. C., Arnold, T. D., Katamura, Y., Giacomini, M. M., Rodriguez, J. D., McCarty, J. H., Pellicoro, A., Raschperger, E., Betsholtz, C., Ruminski, P. G., et al. (2013) · Nature Medicine

Liver physiology and pathologyCell Adhesion Molecules Research

Cited by 866

Decoding myofibroblast origins in human kidney fibrosis

Kuppe, C., Ibrahim, M. M., Kranz, J., Zhang, X., Ziegler, S., Perales-Patón, J., Jansen, J., Reimer, K. C., Smith, J. R., Dobie, R., et al. (2021) · Nature

Chronic Kidney Disease and DiabetesAcute Kidney Injury Research

Cited by 769

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

Tsukui, T., Sun, K.-H., Wetter, J. B., Wilson-Kanamori, J. R., Hazelwood, L. A., Henderson, N. C., Adams, T. S., Schupp, J. C., Poli, S. D., Rosas, I. O., et al. (2020) · Nature Communications

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisSingle-cell and spatial transcriptomics

Cited by 765

Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis

Henderson, N. C., Mackinnon, A. C., Farnworth, S. L., Kipari, T., Haslett, C., Iredale, J. P., Liu, F.-T., Hughes, J., & Sethi, T. (2008) · The American Journal of Pathology

Galectins and Cancer BiologyChronic Kidney Disease and Diabetes

Cited by 562

Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis

Dobie, R., Wilson-Kanamori, J. R., Henderson, B. E. P., Smith, J. R., Matchett, K. P., Portman, J. R., Wallenborg, K., Picelli, S., Zagorska, A., Pendem, S. V., et al. (2019) · Cell Reports

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 420

Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation

Fabre, T., Barron, A. M. S., Christensen, S. M., Asano, S., Bound, K., Lech, M. P., Wadsworth, M. H., Chen, X., Wang, C., Wang, J., et al. (2023) · Science Immunology

Liver physiology and pathologyCardiac Fibrosis and Remodeling

Cited by 355

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Filliol, A., Saito, Y., Nair, A., Dapito, D. H., Yu, L.-X., Ravichandra, A., Bhattacharjee, S., Affo, S., Fujiwara, N., Su, H., et al. (2022) · Nature

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 349

Liver fibrosis: cellular mechanisms of progression and resolution

Henderson, N. C., & Iredale, J. P. (2007) · Clinical Science

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 270

Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis

Ramachandran, P., Matchett, K. P., Dobie, R., Wilson-Kanamori, J. R., & Henderson, N. C. (2020) · Nature Reviews Gastroenterology & Hepatology

Single-cell and spatial transcriptomicsLiver physiology and pathology

Cited by 253

A macrophage-pericyte axis directs tissue restoration via amphiregulin-induced transforming growth factor beta activation

Minutti, C. M., Modak, R. V., Macdonald, F., Li, F., Smyth, D. J., Dorward, D. A., Blair, N., Husovsky, C., Muir, A., Giampazolias, E., et al. (2019) · Immunity

Wound Healing and TreatmentsTGF-β signaling in diseases

Cited by 228

An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis

Wang, S., Li, K., Pickholz, E., Dobie, R., Matchett, K. P., Henderson, N. C., Carrico, C., Driver, I., Borch Jensen, M., Chen, L., et al. (2023) · Science Translational Medicine

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 176

Multimodal decoding of human liver regeneration

Matchett, K. P., Wilson-Kanamori, J. R., Portman, J. R., Kapourani, C. A., Fercoq, F., May, S., Zajdel, E., Beltran, M., Sutherland, E. F., Mackey, J. B. G., et al. (2024) · Nature

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 140

Understanding the cellular interactome of non-alcoholic fatty liver disease

Wallace, S. J., Tacke, F., Schwabe, R. F., & Henderson, N. C. (2022) · JHEP Reports

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 116

Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

Kotsiliti, E., Leone, V., Schuehle, S., Govaere, O., Li, H., Wolf, M. J., Horvatic, H., Bierwirth, S., Hundertmark, J., Inverso, D., et al. (2023) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 108

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

Campana, L., Starkey Lewis, P. J., Pellicoro, A., Aucott, R. L., Man, J., O’Duibhir, E., Mok, S. E., Ferreira-Gonzalez, S., Livingstone, E., Greenhalgh, S. N., et al. (2018) · The Journal of Immunology

Phagocytosis and Immune RegulationLiver physiology and pathology

Cited by 107

The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

Mederacke, I., Filliol, A., Affo, S., Nair, A., Hernandez, C., Sun, Q., Hamberger, F., Brundu, F., Chen, Y., Ravichandra, A., et al. (2022) · Science Translational Medicine

Adenosine and Purinergic SignalingLiver physiology and pathology

Cited by 103

Origins of fibrosis: pericytes take centre stage

Greenhalgh, S. N., Iredale, J. P., & Henderson, N. C. (2013) · F1000Prime Reports

Liver physiology and pathologyInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 96

Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair

De Ponti, F. F., Bujko, A., Liu, Z., Collins, P. J., Schuermans, S., Maueroder, C., Amstelveen, S., Thoné, T., Martens, L., McKendrick, J. G., et al. (2025) · Immunity

Liver physiology and pathologyImmune cells in cancer

Cited by 94

Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy

Richter, M. L., Deligiannis, I. K., Yin, K., Danese, A., Lleshi, E., Coupland, P., Vallejos, C. A., Matchett, K. P., Henderson, N. C., Colome-Tatche, M., et al. (2021) · Nature Communications

Single-cell and spatial transcriptomicsLiver physiology and pathology

Cited by 75

Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation

Cordero-Espinoza, L., Dowbaj, A. M., Kohler, T. N., Strauss, B., Sarlidou, O., Belenguer, G., Pacini, C., Martins, N. P., Dobie, R., Wilson-Kanamori, J. R., et al. (2021) · Cell Stem Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 74

Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

O’Sullivan, E. D., Mylonas, K. J., Bell, R., Carvalho, C., Baird, D. P., Cairns, C., Gallagher, K. M., Campbell, R., Docherty, M., Laird, A., et al. (2022) · JCI Insight

Telomeres, Telomerase, and SenescenceAcute Kidney Injury Research

Cited by 43