Zhang, Ziyang

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., O’Meara, M. J., Rezelj, V. V., Guo, J. Z., Swaney, D. L., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery Methods

Cited by 4,405

Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile

Zhang, Z., Morstein, J., Ecker, A. K., Guiley, K. Z., & Shokat, K. M. (2022) · Journal of the American Chemical Society

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 159

Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)

Zhang, Z., Guiley, K. Z., & Shokat, K. M. (2022) · Nature Chemical Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 153

A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy

Zhang, Z., Rohweder, P. J., Ongpipattanakul, C., Basu, K., Bohn, M.-F., Dugan, E. J., Steri, V., Hann, B., Shokat, K. M., & Craik, C. S. (2022) · Cancer Cell

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 136

GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf

Zhang, Z., Gao, R., Hu, Q., Peacock, H., Peacock, D. M., Dai, S., Shokat, K. M., & Suga, H. (2020) · ACS Central Science

Protein Kinase Regulation and GTPase SignalingChemical Synthesis and Analysis

Cited by 124

KRAS is vulnerable to reversible switch-II pocket engagement in cells

Vasta, J. D., Peacock, D. M., Zheng, Q., Walker, J. A., Zhang, Z., Zimprich, C. A., Thomas, M. R., Beck, M. T., Binkowski, B. F., Corona, C. R., et al. (2022) · Nature Chemical Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 115

Bifunctional Small‐Molecule Ligands of K‐Ras Induce Its Association with Immunophilin Proteins

Zhang, Z., & Shokat, K. M. (2019) · Angewandte Chemie International Edition

Protein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

Cited by 66

IFITM proteins assist cellular uptake of diverse linked chemotypes

Lou, K., Wassarman, D. R., Yang, T., Paung, Y., Zhang, Z., O’Loughlin, T. A., Moore, M. K., Egan, R. K., Greninger, P., Benes, C. H., et al. (2022) · Science

Drug Transport and Resistance MechanismsRNA Interference and Gene Delivery

Cited by 42