Shi, Yigong

Serine/threonine phosphatases: mechanism through structure

Shi, Y. (2009) · Cell

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 1,488

Molecular Architecture of the SARS-CoV-2 Virus

Yao, H., Song, Y., Chen, Y., Wu, N., Xu, J., Sun, C., Zhang, J., Weng, T., Zhang, Z., Wu, Z., et al. (2020) · Cell

SARS-CoV-2 and COVID-19 ResearchAdvanced Electron Microscopy Techniques and Applications

Cited by 1,060

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

Chai, J., Du, C., Wu, J.-W., Kyin, S., Wang, X., & Shi, Y. (2000) · Nature

Cell death mechanisms and regulationUbiquitin and proteasome pathways

Cited by 864

Structure of the Protein Phosphatase 2A Holoenzyme

Xu, Y., Xing, Y., Chen, Y., Chao, Y., Lin, Z., Fan, E., Yu, J. W., Strack, S., Jeffrey, P. D., & Shi, Y. (2006) · Cell

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 450

Mechanisms of AIF-Mediated Apoptotic DNA Degradation in Caenorhabditis elegans

Wang, X., Yang, C., Chai, J., Shi, Y., & Xue, D. (2002) · Science

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 393

Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

Sun, L., Zhou, R., Yang, G., & Shi, Y. (2017) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 382

Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

Xing, Y., Xu, Y., Chen, Y., Jeffrey, P. D., Chao, Y., Lin, Z., Li, Z., Strack, S., Stock, J. B., & Shi, Y. (2006) · Cell

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 334

Recognition of the amyloid precursor protein by human γ-secretase

Zhou, R., Yang, G., Guo, X., Zhou, Q., Lei, J., & Shi, Y. (2019) · Science

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 304

Structure of the human PKD1-PKD2 complex

Su, Q., Hu, F., Ge, X., Lei, J., Yu, S., Wang, T., Zhou, Q., Mei, C., & Shi, Y. (2018) · Science

Genetic and Kidney Cyst DiseasesIon Channels and Receptors

Cited by 284

Structure of a yeast activated spliceosome at 3.5 Å resolution

Yan, C., Wan, R., Bai, R., Huang, G., & Shi, Y. (2016) · Science

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 261

Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53–MDM2 Pathway

Hu, M., Gu, L., Li, M., Jeffrey, P. D., Gu, W., & Shi, Y. (2006) · PLoS Biology

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 251

Structural mechanism of demethylation and inactivation of protein phosphatase 2A

Xing, Y., Li, Z., Chen, Y., Stock, J. B., Jeffrey, P. D., & Shi, Y. (2008) · Cell

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 206

Structural basis of γ-secretase inhibition and modulation by small molecule drugs

Yang, G., Zhou, R., Guo, X., Yan, C., Lei, J., & Shi, Y. (2021) · Cell

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Cited by 189

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

Shiozaki, E. N., Gu, L., Yan, N., & Shi, Y. (2004) · Molecular Cell

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 174

Structure and mechanism of the S component of a bacterial ECF transporter

Zhang, P., Wang, J., & Shi, Y. (2010) · Nature

Drug Transport and Resistance MechanismsEnzyme Structure and Function

Cited by 99

Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex

Huang, G., Zhan, X., Zeng, C., Liang, K., Zhu, X., Zhao, Y., Wang, P., Wang, Q., Zhou, Q., Tao, Q., et al. (2022) · Cell Research

Nuclear Structure and FunctionProtein Structure and Dynamics

Cited by 33

Cryo-EM structure of the Inner Ring from Xenopus laevis Nuclear Pore Complex

Huang, G., Zhan, X., Zeng, C., Liang, K., Zhu, X., Zhao, Y., Wang, P., Wang, Q., Zhou, Q., Tao, Q., et al. (2021) · Cell Research

Nuclear Structure and FunctionProtein Structure and Dynamics

Cited by 33

Structural basis of auxin binding and transport by Arabidopsis thaliana AUX1

Jing, D., Kong, F., Lu, X., Huang, G., Huang, J., Wang, H., Shi, Y., & Wang, C. (2025) · Proceedings of the National Academy of Sciences

Plant Molecular Biology ResearchDrug Transport and Resistance Mechanisms

Cited by 4

Structural basis of auxin binding and transport by Arabidopsis thaliana AUX1

Jing, D., Kong, F., Lu, X., Huang, G., Huang, J., Wang, H., Shi, Y., & Wang, C. (2025) · Proceedings of the National Academy of Sciences

Plant Molecular Biology ResearchDrug Transport and Resistance Mechanisms

Cited by 4