Zhou, Daohong

Cellular Senescence: Defining a Path Forward

Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 3,225

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,819

Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,338

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

Khan, S., Zhang, X., Lv, D., Zhang, Q., He, Y., Zhang, P., Liu, X., Thummuri, D., Yuan, Y., Wiegand, J. S., et al. (2019) · Nature Medicine

Protein Degradation and InhibitorsCell death mechanisms and regulation

Cited by 688

Exposure to physical and psychological stressors elevates plasma interleukin 6: Relationship to the activation of hypothalamic-pituitary-adrenal axis

Zhou, D., Kusnecov, A. W., Shurin, M. R., DePaoli, M., & Rabin, B. S. (1993) · Endocrinology

Stress Responses and CortisolTryptophan and brain disorders

Cited by 494

Total body irradiation selectively induces murine hematopoietic stem cell senescence.

Wang, Y., Schulte, B. A., LaRue, A. C., Ogawa, M., & Zhou, D. (2006) · Blood

Hematopoietic Stem Cell TransplantationTelomeres, Telomerase, and Senescence

Cited by 351

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

He, Y., Zhang, X., Chang, J., Kim, H.-N., Zhang, P., Wang, Y., Khan, S., Liu, X., Zhang, X., Lv, D., et al. (2020) · Nature Communications

Protein Degradation and InhibitorsTelomeres, Telomerase, and Senescence

Cited by 280

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

Wang, Y., Chang, J., Liu, X., Zhang, X., Zhang, S., Zhang, X., Zhou, D., & Zheng, G. (2016) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 274

Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells

Wang, Y., Liu, L., Pazhanisamy, S. K., Li, H., Meng, A., & Zhou, D. (2010) · Free Radical Biology and Medicine

Effects of Radiation ExposureHematopoietic Stem Cell Transplantation

Cited by 273

IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis

Faust, H. J., Zhang, H., Han, J., Wolf, M. T., Jeon, O. H., Sadtler, K., Peña, A. N., Chung, L., Maestas, D. R., Tam, A. J., et al. (2020) · Journal of Clinical Investigation

Osteoarthritis Treatment and MechanismsTelomeres, Telomerase, and Senescence

Cited by 260

PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics

Khan, S., He, Y., Zhang, X., Yuan, Y., Pu, S., Kong, Q., Zheng, G., & Zhou, D. (2020) · Oncogene

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 252

DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age

Kim, H., Chang, J., Shao, L., Han, L., Iyer, S., Manolagas, S. C., O'Brien, C. A., Jilka, R. L., Zhou, D., & Almeida, M. (2017) · Aging Cell

Bone Metabolism and DiseasesTelomeres, Telomerase, and Senescence

Cited by 192

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition

Johnson, S. M., Torrice, C. D., Bell, J. F., Monahan, K. B., Jiang, Q., Wang, Y., Ramsey, M. R., Jin, J., Wong, K.-K., Su, L., et al. (2010) · Journal of Clinical Investigation

Effects of Radiation ExposureHematopoietic Stem Cell Transplantation

Cited by 168

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

Shao, L., Feng, W., Li, H., Gardner, D., Luo, Y., Wang, Y., Liu, L., Meng, A., Sharpless, N. E., & Zhou, D. (2014) · Blood

Hematopoietic Stem Cell TransplantationEffects of Radiation Exposure

Cited by 165

The curcumin analog EF24 is a novel senolytic agent

Li, W., He, Y., Zhang, R., Zheng, G., & Zhou, D. (2019) · Aging

Telomeres, Telomerase, and SenescenceCurcumin's Biomedical Applications

Cited by 164

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,

Lv, D., Pal, P., Liu, X., Jia, Y., Thummuri, D., Zhang, P., Hu, W., Pei, J., Zhang, Q., Zhou, S., et al. (2021) · Nature Communications

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 158

DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

He, Y., Koch, R., Budamagunta, V., Zhang, P., Zhang, X., Khan, S., Thummuri, D., Ortiz, Y. T., Zhang, X., Lv, D., et al. (2020) · Journal of Hematology & Oncology

Protein Degradation and InhibitorsCell death mechanisms and regulation

Cited by 139

Oxidation resistance 1 is a novel senolytic target

Zhang, X., Zhang, S., Liu, X., Wang, Y., Chang, J., Zhang, X., Mackintosh, S. G., Tackett, A. J., He, Y., Lv, D., et al. (2018) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 127

Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies

He, Y., Khan, S., Huo, Z., Lv, D., Zhang, X., Liu, X., Yuan, Y., Hromas, R., Xu, M., Zheng, G., et al. (2020) · Journal of Hematology & Oncology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 126

Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity

Zhang, X., Thummuri, D., Liu, X., Hu, W., Zhang, P., Khan, S., Yuan, Y., Zhou, D., & Zheng, G. (2020) · European Journal of Medicinal Chemistry

Protein Degradation and InhibitorsCell death mechanisms and regulation

Cited by 123

Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence

Kim, H.-N., Xiong, J., MacLeod, R. S., Iyer, S., Fujiwara, Y., Cawley, K. M., Han, L., He, Y., Thostenson, J. D., Ferreira, E., et al. (2020) · JCI Insight

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 117

Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway

Probin, V., Wang, Y., & Zhou, D. (2007) · Free Radical Biology and Medicine

Telomeres, Telomerase, and SenescenceRedox biology and oxidative stress

Cited by 105

Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-X L

Zhang, X., Thummuri, D., He, Y., Liu, X., Zhang, P., Zhou, D., & Zheng, G. (2019) · Chemical Communications

Protein Degradation and InhibitorsCell death mechanisms and regulation

Cited by 86

Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation

Liu, X., Wang, Y., Zhang, X., Gao, Z., Zhang, S., Shi, P., Zhang, X., Song, L., Hendrickson, H., Zhou, D., et al. (2018) · Bioorganic & Medicinal Chemistry

Telomeres, Telomerase, and SenescencePiperaceae Chemical and Biological Studies

Cited by 77