Yang, Andrew C.

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

The Tabula Muris Consortium, Almanzar, N., Antony, J., Baghel, A. S., Bakerman, I., Bansal, I., Barres, B. A., Beachy, P. A., Berdnik, D., Bilen, B., et al. (2020) · Nature

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

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Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

Gate, D., Saligrama, N., Leventhal, O., Yang, A. C., Unger, M. S., Middeldorp, J., Chen, K., Lehallier, B., Channappa, D., De Los Santos, M. B., et al. (2020) · Nature

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

Yang, A. C., Vest, R. T., Kern, F., Lee, D. P., Agam, M., Maat, C. A., Losada, P. M., Chen, M. B., Schaum, N., Khoury, N., et al. (2022) · Nature

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 797

Ageing hallmarks exhibit organ-specific temporal signatures

Schaum, N., Lehallier, B., Hahn, O., Pálovics, R., Hosseinzadeh, S., Lee, S. E., Sit, R., Lee, D. P., Losada, P. M., Zardeneta, M. E., et al. (2020) · Nature

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 671

Organ aging signatures in the plasma proteome track health and disease

Oh, H. S.-H., Rutledge, J., Nachun, D., Pálovics, R., Abiose, O., Moran-Losada, P., Channappa, D., Urey, D. Y., Kim, K., Sung, Y. J., et al. (2023) · Nature

Genetics, Aging, and Longevity in Model OrganismsDementia and Cognitive Impairment Research

Cited by 634

Dysregulation of brain and choroid plexus cell types in severe COVID-19

Yang, A. C., Kern, F., Losada, P. M., Agam, M. R., Maat, C. A., Schmartz, G. P., Fehlmann, T., Stein, J. A., Schaum, N., Lee, D. P., et al. (2021) · Nature

Long-Term Effects of COVID-19Single-cell and spatial transcriptomics

Cited by 620

Physiological blood–brain transport is impaired with age by a shift in transcytosis

Yang, A. C., Stevens, M. Y., Chen, M. B., Lee, D. P., Stähli, D., Gate, D., Contrepois, K., Chen, W., Iram, T., Zhang, L., et al. (2020) · Nature

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 477

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

Pluvinage, J. V., Haney, M. S., Smith, B. A. H., Sun, J., Iram, T., Bonanno, L., Li, L., Lee, D. P., Morgens, D. W., Yang, A. C., et al. (2019) · Nature

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 459

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

Yousef, H., Czupalla, C. J., Lee, D., Chen, M. B., Burke, A. N., Zera, K. A., Zandstra, J., Berber, E., Lehallier, B., Mathur, V., et al. (2019) · Nature Medicine

Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

Cited by 442

Exercise plasma boosts memory and dampens brain inflammation via clusterin

De Miguel, Z., Khoury, N., Betley, M. J., Lehallier, B., Willoughby, D., Olsson, N., Yang, A. C., Hahn, O., Lu, N., Vest, R. T., et al. (2021) · Nature

Neuroinflammation and Neurodegeneration MechanismsClusterin in disease pathology

Cited by 422

An exercise-inducible metabolite that suppresses feeding and obesity

Li, V. L., He, Y., Contrepois, K., Liu, H., Kim, J. T., Wiggenhorn, A. L., Tanzo, J. T., Tung, A. S.-H., Lyu, X., Zushin, P.-J. H., et al. (2022) · Nature

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 331

Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

Chen, M. B., Yang, A. C., Yousef, H., Lee, D., Chen, W., Schaum, N., Lehallier, B., Quake, S. R., & Wyss-Coray, T. (2020) · Cell Reports

Barrier Structure and Function StudiesGenetics, Aging, and Longevity in Model Organisms

Cited by 233

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

Pálovics, R., Keller, A., Schaum, N., Tan, W., Fehlmann, T., Borja, M., Kern, F., Bonanno, L., Calcuttawala, K., Webber, J., et al. (2022) · Nature

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 153

A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease risk

Yang, A. C., Vest, R. T., Kern, F., Lee, D. P., Maat, C. A., Losada, P. M., Chen, M. B., Agam, M., Schaum, N., Khoury, N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

Barrier Structure and Function StudiesSingle-cell and spatial transcriptomics

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