Wang, Zhizhi

MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex

Cheng, T.-L., Wang, Z., Liao, Q., Zhu, Y., Zhou, W.-H., Xu, W., & Qiu, Z. (2014) · Developmental Cell

Genetics and Neurodevelopmental DisordersMicroRNA in disease regulation

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Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

Sangodkar, J., Perl, A., Tohme, R., Kiselar, J., Kastrinsky, D. B., Zaware, N., Izadmehr, S., Mazhar, S., Wiredja, D. D., O’Connor, C. M., et al. (2017) · Journal of Clinical Investigation

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

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Selective PP2A enhancement through biased heterotrimer stabilization

Leonard, D., Huang, W., Izadmehr, S., O’Connor, C. M., Wiredja, D. D., Wang, Z., Zaware, N., Chen, Y., Schlatzer, D. M., Kiselar, J., et al. (2020) · Cell

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

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Crystal structure of a membrane-bound O-acyltransferase

Ma, D., Wang, Z., Merrikh, C. N., Lang, K. S., Lu, P., Li, X., Merrikh, H., Rao, Z., & Xu, W. (2018) · Nature

Bacterial Genetics and BiotechnologyEnzyme Structure and Function

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Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56

Wang, J., Okkeri, J., Pavic, K., Wang, Z., Kauko, O., Halonen, T., Sarek, G., Ojala, P. M., Rao, Z., Xu, W., et al. (2017) · The EMBO Reports

Cancer Mechanisms and TherapySignaling Pathways in Disease

Cited by 95

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization

Wang, J., Wang, Z., Yu, T., Yang, H., Virshup, D. M., Kops, G. J. P. L., Lee, S. H., Zhou, W., Li, X., Xu, W., et al. (2016) · Protein & Cell

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 80

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

O’Connor, C. M., Leonard, D., Wiredja, D., Avelar, R. A., Wang, Z., Schlatzer, D., Bryson, B., Tokala, E., Taylor, S. E., Upadhyay, A., et al. (2020) · Oncogene

Protein Tyrosine PhosphatasesMelanoma and MAPK Pathways

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Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7)

Qin, J., Wang, Z., Hoogeveen-Westerveld, M., Shen, G., Gong, W., Nellist, M., & Xu, W. (2016) · Journal of Biological Chemistry

Tuberous Sclerosis Complex ResearchPI3K/AKT/mTOR signaling in cancer

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Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations

Sun, W., Zhu, Y. J., Wang, Z., Zhong, Q., Gao, F., Lou, J., Gong, W., & Xu, W. (2013) · Nature Communications

Tuberous Sclerosis Complex ResearchPI3K/AKT/mTOR signaling in cancer

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