Xu, Haijin

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

Okiyoneda, T., Veit, G., Dekkers, J. F., Bagdany, M., Soya, N., Xu, H., Roldan, A., Verkman, A. S., Kurth, M., Simon, A., et al. (2013) · Nature Chemical Biology

Cystic Fibrosis Research AdvancesIon Transport and Channel Regulation

Cited by 378

Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function

Rabeh, W. M., Bossard, F., Xu, H., Okiyoneda, T., Bagdany, M., Mulvihill, C. M., Du, K., di Bernardo, S., Liu, Y., Konermann, L., et al. (2012) · Cell

Cystic Fibrosis Research AdvancesProtein Structure and Dynamics

Cited by 280

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination

Veit, G., Roldan, A., Hancock, M. A., Da Fonte, D. F., Xu, H., Hussein, M., Frenkiel, S., Matouk, E., Velkov, T., & Lukacs, G. L. (2020) · JCI Insight

Cystic Fibrosis Research AdvancesIon Transport and Channel Regulation

Cited by 250

Structure-guided combination therapy to potently improve the function of mutant CFTRs

Veit, G., Xu, H., Dreano, E., Avramescu, R. G., Bagdany, M., Beitel, L. K., Roldan, A., Hancock, M. A., Lay, C., Li, W., et al. (2018) · Nature Medicine

Cystic Fibrosis Research AdvancesGenetic and Kidney Cyst Diseases

Cited by 134

Mutation-specific downregulation of CFTR2 variants by gating potentiators

Avramescu, R. G., Kai, Y., Xu, H., Bidaud-Meynard, A., Schnúr, A., Frenkiel, S., Matouk, E., Veit, G., & Lukacs, G. L. (2017) · Human Molecular Genetics

Cystic Fibrosis Research AdvancesInhalation and Respiratory Drug Delivery

Cited by 43

Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca2+-induced proteostasis disease stress

Wang, B. B., Xu, H., Isenmann, S., Huang, C., Elorza-Vidal, X., Rychkov, G. Y., Estévez, R., Schittenhelm, R. B., Lukacs, G. L., & Apaja, P. M. (2022) · Cellular and Molecular Life Sciences

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 10

Ubr1-induced selective endo-phagy/autophagy protects against the endosomal and Ca 2+ -induced proteostasis disease stress

Wang, B. B., Xu, H., Isenmann, S., Huang, C., Elorza-Vidal, X., Rychkov, G. Y., Estévez, R., Schittenhelm, R. B., Lukacs, G. L., & Apaja, P. M. (2021) · Cellular and Molecular Life Sciences

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 10