Baker, Amanda F.

A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination

Ramanathan, R. K., Abbruzzese, J., Dragovich, T., Kirkpatrick, L., Guillen, J. M., Baker, A. F., Pestano, L. A., Green, S., & Von Hoff, D. D. (2011) · Cancer Chemotherapy and Pharmacology

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 122

TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules

Liu, Q., Sun, J. D., Wang, J., Ahluwalia, D., Baker, A. F., Cranmer, L. D., Ferraro, D., Wang, Y., Duan, J.-X., Ammons, W. S., et al. (2012) · Cancer Chemotherapy and Pharmacology

Cancer, Hypoxia, and MetabolismBioactive Compounds and Antitumor Agents

Cited by 113

The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma

Baker, A. F., Dragovich, T., Tate, W. R., Ramanathan, R. K., Roe, D., Hsu, C.-H., Kirkpatrick, D. L., & Powis, G. (2006) · Journal of Laboratory and Clinical Medicine

Redox biology and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 90

IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic cancer cell lines

Block, K. M., Hanke, N. T., Maine, E. A., & Baker, A. F. (2012) · Pancreas

Cytokine Signaling Pathways and InteractionsPancreatic and Hepatic Oncology Research

Cited by 62

A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers

Baker, A. F., Adab, K. N., Raghunand, N., Chow, H. H. S., Stratton, S. P., Squire, S. W., Boice, M., Pestano, L. A., Kirkpatrick, D. L., & Dragovich, T. (2013) · Investigational New Drugs

Redox biology and oxidative stressGastric Cancer Management and Outcomes

Cited by 52

Antitumor agent PX-12 inhibits HIF-1α protein levels through an Nrf2/PMF-1-mediated increase in spermidine/spermine acetyl transferase

Kim, Y. H., Coon, A., Baker, A. F., & Powis, G. (2011) · Cancer Chemotherapy and Pharmacology

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 45