Leone, Gustavo

The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis

Han, L., Wu, Y., Fang, K., Sweeney, S., Roesner, U. K., Parrish, M., Patel, K., Walter, T., Piermattei, J., Trimboli, A., et al. (2023) · Nature Communications

Pancreatic and Hepatic Oncology ResearchPancreatic function and diabetes

Cited by 369

Identification and Characterization of E2F7, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation

de Bruin, A., Maiti, B., Jakoi, L., Timmers, C., Buerki, R., & Leone, G. (2003) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 221

The Accumulation of an E2F-p130 Transcriptional Repressor Distinguishes a G0 Cell State From a G1 Cell State

Smith, E. J., Leone, G., DeGregori, J., Jakoi, L., & Nevins, J. R. (1996) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 218

Rb regulates proliferation and rod photoreceptor development in the mouse retina

Zhang, J., Gray, J., Wu, L., Leone, G., Rowan, S., Cepko, C. L., Zhu, X., Craft, C. M., & Dyer, M. A. (2004) · Nature Genetics

Retinal Development and DisordersNeurogenesis and neuroplasticity mechanisms

Cited by 190

Ets1 and ets2 are required for endothelial cell survival during embryonic angiogenesis

Wei, G., Srinivasan, R., Cantemir-Stone, C. Z., Sharma, S. M., Santhanam, R., Weinstein, M., Muthusamy, N., Man, A. K., Oshima, R. G., Leone, G., et al. (2009) · Blood

Angiogenesis and VEGF in CancerDevelopmental Biology and Gene Regulation

Cited by 185

Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation

Ahirwar, D. K., Nasser, M. W., Ouseph, M. M., Elbaz, M., Cuitiño, M. C., Kladney, R. D., Varikuti, S., Kaul, K., Satoskar, A. R., Ramaswamy, B., et al. (2018) · Oncogene

Chemokine receptors and signalingAngiogenesis and VEGF in Cancer

Cited by 162

Canonical and atypical E2Fs regulate the mammalian endocycle

Chen, H.-Z., Ouseph, M. M., Li, J., Pécot, T., Chokshi, V., Kent, L., Bae, S., Byrne, M., Duran, C., Comstock, G., et al. (2012) · Nature Cell Biology

Cancer-related Molecular PathwaysDevelopmental Biology and Gene Regulation

Cited by 161

Division and apoptosis of E2f-deficient retinal progenitors

Chen, D., Pacal, M., Wenzel, P., Knoepfler, P. S., Leone, G., & Bremner, R. (2009) · Nature

Cancer-related Molecular PathwaysRetinal Development and Disorders

Cited by 144

E2f8 mediates tumor suppression in postnatal liver development

Kent, L. N., Rakijas, J. B., Pandit, S. K., Westendorp, B., Chen, H.-Z., Huntington, J. T., Tang, X., Bae, S., Srivastava, A., Senapati, S., et al. (2016) · Journal of Clinical Investigation

Cancer-related Molecular PathwaysLiver physiology and pathology

Cited by 95

HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer

Rath, K. S., Naidu, S. K., Lata, P., Bid, H. K., Rivera, B. K., McCann, G. A., Tierney, B. J., ElNaggar, A. C., Bravo, V., Leone, G., et al. (2014) · Cancer Research

Cytokine Signaling Pathways and InteractionsHeterocyclic Compound Synthesis and Bioactivity

Cited by 95

Rb-Mediated Neuronal Differentiation through Cell-Cycle–Independent Regulation of E2f3a

Chen, D., Opavsky, R., Pacal, M., Tanimoto, N., Wenzel, P., Seeliger, M. W., Leone, G., & Bremner, R. (2007) · PLoS Biology

Retinal Development and DisordersNeurogenesis and neuroplasticity mechanisms

Cited by 91

Unique Requirement for Rb/E2F3 in Neuronal Migration: Evidence for Cell Cycle-Independent Functions

McClellan, K. A., Ruzhynsky, V. A., Douda, D. N., Vanderluit, J. L., Ferguson, K. L., Chen, D., Bremner, R., Park, D. S., Leone, G., & Slack, R. S. (2007) · Molecular and Cellular Biology

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 88