Torrent, Maricel

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Lasko, L. M., Jakob, C. G., Edalji, R. P., Qiu, W., Montgomery, D., Digiammarino, E. L., Hansen, T. M., Risi, R. M., Frey, R., Manaves, V., et al. (2017) · Nature

Histone Deacetylase Inhibitors ResearchProtein Degradation and Inhibitors

Cited by 858

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Faivre, E. J., McDaniel, K. F., Albert, D. H., Mantena, S. R., Plotnik, J. P., Wilcox, D., Zhang, L., Bui, M. H., Sheppard, G. S., Wang, L., et al. (2020) · Nature

Protein Degradation and InhibitorsProstate Cancer Treatment and Research

Cited by 408

WD40 repeat domain proteins: a novel target class?

Schapira, M., Tyers, M., Torrent, M., & Arrowsmith, C. H. (2017) · Nature Reviews Drug Discovery

Protein Degradation and InhibitorsChemical Synthesis and Analysis

Cited by 335

The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

He, Y., Selvaraju, S., Curtin, M. L., Jakob, C. G., Zhu, H., Comess, K. M., Shaw, B., The, J., Lima-Fernandes, E., Szewczyk, M. M., et al. (2017) · Nature Chemical Biology

Epigenetics and DNA MethylationCancer-related gene regulation

Cited by 224

A TSHβ Variant with Impaired Immunoreactivity but Intact Biological Activity and Its Clinical Implications

Pappa, T., Johannesen, J., Scherberg, N., Torrent, M., Dumitrescu, A., & Refetoff, S. (2015) · Thyroid

Thyroid Disorders and TreatmentsGenomics and Rare Diseases

Cited by 19

PINNED: Identifying Characteristics of Druggable Human Proteins Using an Interpretable Neural Network

Cunningham, M., Pins, D., Dezso, Z., Torrent, M., Vasanthakumar, A., & Pandey, A. (2023) · Journal of Cheminformatics

Computational Drug Discovery MethodsMachine Learning in Bioinformatics

Cited by 13

PINNED: identifying characteristics of druggable human proteins using an interpretable neural network

Cunningham, M., Pins, D., Dezső, Z., Torrent, M., Vasanthakumar, A., & Pandey, A. (2023) · Journal of Cheminformatics

Computational Drug Discovery MethodsMachine Learning in Bioinformatics

Cited by 13