Timsina, Jigyasha

Organ aging signatures in the plasma proteome track health and disease

Oh, H. S.-H., Rutledge, J., Nachun, D., Pálovics, R., Abiose, O., Moran-Losada, P., Channappa, D., Urey, D. Y., Kim, K., Sung, Y. J., et al. (2023) · Nature

Genetics, Aging, and Longevity in Model OrganismsDementia and Cognitive Impairment Research

Cited by 634

Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer's disease

Cruchaga, C., Western, D., Timsina, J., Wang, L., Wang, C., Yang, C., Ali, M., Beric, A., Gorijala, P., Kohlfeld, P., et al. (2023) · Nature Genetics

Genetic Associations and EpidemiologyAlzheimer's disease research and treatments

Cited by 112

Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer’s disease

Western, D., Timsina, J., Wang, L., Wang, C., Yang, C., Phillips, B., Wang, Y., Liu, M., Ali, M., Beric, A., et al. (2024) · Nature Genetics

Genetic Associations and EpidemiologyAlzheimer's disease research and treatments

Cited by 111

Comparative analysis of Alzheimer's disease cerebrospinal fluid biomarkers measurement by multiplex SOMAscan platform and immunoassay‐based approach

Timsina, J., Gomez-Fonseca, D., Wang, L., Do, A., Western, D., Alvarez, I., Aguilar, M., Pastor, P., Henson, R. L., Herries, E., et al. (2022) · Journal of Alzheimer’s Disease

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 68

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum

Ali, M., Timsina, J., Western, D., Liu, M., Beric, A., Budde, J., Do, A., Heo, G., Wang, L., Gentsch, J., et al. (2025) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 61

Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer’s disease

Wang, L., Nykänen, N.-P., Western, D., Gorijala, P., Timsina, J., Li, F., Wang, Z., Ali, M., Yang, C., Marquié, M., et al. (2023) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 59

Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer’s disease

Wang, L., Nykänen, N.-P., Western, D., Gorijala, P., Timsina, J., Li, F., Wang, Z., Ali, M., Yang, C., Liu, M., et al. (2024) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 58

Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable for Parkinson’s disease

Phillips, B., Western, D., Wang, L., Timsina, J., Sun, Y., Gorijala, P., Yang, C., Do, A., Nykänen, N.-P., Alvarez, I., et al. (2023) · npj Parkinson s Disease

Parkinson's Disease Mechanisms and TreatmentsGenetic Associations and Epidemiology

Cited by 20

Proteo‐genomics of soluble TREM2 in cerebrospinal fluid provides novel insights for TREM2 biology and identifies novel modulators for Alzheimer’s disease

Wang, L., Nykanen, N., Western, D., Gorijala, P., Timsina, J., Marquié, M., Boada, M., Alvarez, I., Aguilar, M., Pastor, P., et al. (2023) · Alzheimer's & Dementia

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 6

A genetic and proteomic comparison of key AD biomarkers across tissues

Marsh, T. W., Western, D., Timsina, J., Gorijala, P., Yang, C., Pastor, P., Liu, M., Morris, J. C., Bateman, R. J., Schindler, S. E., et al. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 6

Multi‐cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease

Ali, M., Timsina, J., Wang, L., Do, A., Western, D., Sung, Y. J., & Cruchaga, C. (2023) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 5

TOPMed imputed genomics enhances genomic atlas of the human proteome in brain, cerebrospinal fluid, and plasma

Yi, H., Yang, Q., Repaci, C., Lee, C. M., Heo, G., Timsina, J., Gorijala, P., Yang, C., Budde, J., Wang, L., et al. (2024) · Scientific Data

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 5

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

Debette, S., Caro, I., Western, D., Namba, S., Sun, N., Kawaguchi, S., He, Y., Fujita, M., Roshchupkin, G., D'Aoust, T., et al. (2024) · Research Square

Cerebrovascular and genetic disordersMultiple Sclerosis Research Studies

Cited by 5

Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease

Western, D., Yang, C., Timsina, J., Liu, M., Wang, C., Campbell, M. C., Kotzbauer, P., Perlmutter, J. S., Schindler, S. E., Morris, J. C., et al. (2026) · Science Translational Medicine

Genetic Associations and EpidemiologyMultiple Sclerosis Research Studies

Cited by 1