Flück, Christa E.

Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management

Claahsen - van der Grinten, H. L., Speiser, P. W., Ahmed, S. F., Arlt, W., Auchus, R. J., Falhammar, H., Flück, C. E., Guasti, L., Huebner, A., Kortmann, B. B. M., et al. (2022) · Endocrine Reviews

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 556

Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome

Flück, C. E., Tajima, T., Pandey, A. V., Arlt, W., Okuhara, K., Verge, C. F., Jabs, E. W., Mendonça, B. B., Fujieda, K., & Miller, W. L. (2004) · Nature Genetics

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 509

Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: Single-arm, open-label, multicentre, phase 3 trials

Clément, K., van den Akker, E., Argente, J., Bahm, A., Chung, W. K., Connors, H., De Waele, K., Farooqi, I. S., Gonneau-Lejeune, J., Gordon, G., et al. (2020) · The Lancet Diabetes & Endocrinology

Regulation of Appetite and ObesityPharmacology and Obesity Treatment

Cited by 492

Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis

Huang, N., Pandey, A. V., Agrawal, V., Reardon, W., Lapunzina, P. D., Mowat, D., Jabs, E. W., Vliet, G. V., Sack, J., Flück, C. E., et al. (2005) · The American Journal of Human Genetics

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 336

NADPH P450 oxidoreductase: Structure, function, and pathology of diseases

Pandey, A. V., & Flück, C. E. (2013) · Pharmacology & Therapeutics

Pharmacogenetics and Drug MetabolismMetabolism and Genetic Disorders

Cited by 279

Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation

Flück, C. E., Meyer-Böni, M., Pandey, A. V., Kempná, P., Miller, W. L., Schoenle, E. J., & Biason-Lauber, A. (2011) · The American Journal of Human Genetics

Sexual Differentiation and DisordersGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Cited by 248

The 17, 20-Lyase Activity of Cytochrome P450c17 from Human Fetal Testis Favors the Δ5Steroidogenic Pathway

Flück, C. E., Miller, W. L., & Auchus, R. J. (2003) · The Journal of Clinical Endocrinology & Metabolism

Steroid Chemistry and BiochemistrySexual Differentiation and Disorders

Cited by 173

The external genitalia score (EGS): a European multicenter validation study

van der Straaten, S., Springer, A., Zecic, A., Hebenstreit, D., Tonnhofer, U., Gawlik, A., Baumert, M., Szeliga, K., Debulpaep, S., Desloovere, A., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersUrological Disorders and Treatments

Cited by 135

Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase

Pandey, A. V., Kempná, P., Hofer, G., Mullis, P. E., & Flück, C. E. (2007) · Molecular Endocrinology

Pharmacogenetics and Drug MetabolismAdrenal Hormones and Disorders

Cited by 132

Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex I activity of the respiratory chain

Hirsch, A., Hahn, D., Kempná, P., Hofer, G., Nuoffer, J.-M., Mullis, P. E., & Flück, C. E. (2012) · Endocrinology

Ovarian function and disordersMetabolism, Diabetes, and Cancer

Cited by 109

Colon cancer cells produce immunoregulatory glucocorticoids

Sidler, D., Renzulli, P., Schnoz, C., Berger, B., Schneider-Jakob, S., Flück, C., Inderbitzin, D., Corazza, N., Candinas, D., & Brunner, T. (2011) · Oncogene

Estrogen and related hormone effectsAdrenal Hormones and Disorders

Cited by 107

Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia

Flück, C. E., Pandey, A. V., Dick, B., Camats, N., Fernández-Cancio, M., Clemente, M., Gussinyé, M., Carrascosa, A., Mullis, P. E., & Audi, L. (2011) · PLoS ONE

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 94

Role of DNA methylation in the tissue-specific expression of the CYP17A1 gene for steroidogenesis in rodents

Missaghian, E., Kempná, P., Dick, B., Hirsch, A., Alikhani-Koupaei, R., Jégou, B., Mullis, P. E., Frey, B. M., & Flück, C. E. (2009) · Journal of Endocrinology

Epigenetics and DNA MethylationAdrenal Hormones and Disorders

Cited by 91

P450 Oxidoreductase deficiency: Analysis of mutations and polymorphisms

Burkhard, F. Z., Parween, S., Udhane, S. S., Flück, C. E., & Pandey, A. V. (2017) · The Journal of Steroid Biochemistry and Molecular Biology

Pharmacogenetics and Drug MetabolismSexual Differentiation and Disorders

Cited by 79

Genes and proteins of the alternative steroid backdoor pathway for dihydrotestosterone synthesis are expressed in the human ovary and seem enhanced in the polycystic ovary syndrome

Marti, N., Galván, J. A., Pandey, A. V., Trippel, M., Tapia, C., Müller, M., Perren, A., & Flück, C. E. (2017) · Molecular and Cellular Endocrinology

Ovarian function and disordersSexual Differentiation and Disorders

Cited by 76

MECHANISMS IN ENDOCRINOLOGY: Update on pathogenesis of primary adrenal insufficiency: beyond steroid enzyme deficiency and autoimmune adrenal destruction

Flück, C. E. (2017) · European Journal of Endocrinology

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 75

Of marsupials and men: “Backdoor” dihydrotestosterone synthesis in male sexual differentiation

Biason-Lauber, A., Miller, W. L., Pandey, A. V., & Flück, C. E. (2013) · Molecular and Cellular Endocrinology

Sexual Differentiation and DisordersGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Cited by 69

A novel mutation L260P of the steroidogenic acute regulatory protein gene in three unrelated patients of Swiss ancestry with congenital lipoid adrenal hyperplasia

Flück, C. E., Maret, A., Mallet, D., Portrat-Doyen, S., Achermann, J. C., Leheup, B., Theintz, G. E., Mullis, P. E., & Morel, Y. (2005) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 59

Reduction in hepatic drug metabolizing CYP3A4 activities caused by P450 oxidoreductase mutations identified in patients with disordered steroid metabolism

Flück, C. E., Mullis, P. E., & Pandey, A. V. (2010) · Biochemical and Biophysical Research Communications

Pharmacogenetics and Drug MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 59

P450 oxidoreductase deficiency: a new form of congenital adrenal hyperplasia

Flück, C. E., & Miller, W. L. (2006) · Current Opinion in Pediatrics

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 57

Butyrate increases intracellular calcium levels and enhances growth hormone release from rat anterior pituitary cells via the G-protein-coupled receptors GPR41 and 43

Miletta, M. C., Petkovic, V., Eblé, A., Ammann, R. A., Flück, C. E., & Mullis, P.-E. (2014) · PLoS ONE

Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormones

Cited by 51

Human 3β-hydroxysteroid dehydrogenase deficiency seems to affect fertility but may not harbor a tumor risk: lesson from an experiment of nature

Burckhardt, M.-A., Udhane, S. S., Marti, N., Schnyder, I., Tapia, C., Nielsen, J. E., Mullis, P. E., Rajpert-De Meyts, E., & Flück, C. E. (2015) · European Journal of Endocrinology

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 49

Sex- and age-specific reference intervals of 16 steroid metabolites quantified simultaneously by LC-MS/MS in sera from 2458 healthy subjects aged 0 to 77 years

Frederiksen, H., Johannsen, T. H., Andersen, S. E., Petersen, J. H., Busch, A. S., Ljubicic, M. L., Fischer, M. B., Upners, E. N., Hagen, C. P., Main, K. M., et al. (2024) · Clinica Chimica Acta

Adrenal Hormones and DisordersClinical Laboratory Practices and Quality Control

Cited by 46

P450 Oxidoreductase Deficiency: Loss of Activity Caused by Protein Instability From a Novel L374H Mutation

Parween, S., Roucher-Boulez, F., Flück, C. E., Lienhardt-Roussie, A., Mallet, D., Morel, Y., & Pandey, A. V. (2016) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 37