Hughes, Beverly A.

Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors

Arlt, W., Biehl, M., Taylor, A. E., Hahner, S., Libé, R., Hughes, B. A., Schneider, P., Smith, D. J., Stiekema, H., Krone, N., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism

Adrenal and Paraganglionic TumorsMetabolomics and Mass Spectrometry Studies

Cited by 458

Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS)

Krone, N., Hughes, B. A., Lavery, G. G., Stewart, P. M., Arlt, W., & Shackleton, C. H. L. (2010) · The Journal of Steroid Biochemistry and Molecular Biology

Metabolism and Genetic DisordersMetabolomics and Mass Spectrometry Studies

Cited by 434

Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism

Arlt, W., Lang, K., Sitch, A. J., Dietz, A. S., Rhayem, Y., Bancos, I., Feuchtinger, A., Chortis, V., Gilligan, L. C., Ludwig, P., et al. (2017) · JCI Insight

Hormonal Regulation and HypertensionAdrenal and Paraganglionic Tumors

Cited by 281

Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study

Bancos, I., Taylor, A. E., Chortis, V., Sitch, A. J., Jenkinson, C., Davidge-Pitts, C. J., Lang, K., Tsagarakis, S., Macech, M., Riester, A., et al. (2020) · The Lancet Diabetes & Endocrinology

Adrenal and Paraganglionic TumorsAdrenal Hormones and Disorders

Cited by 250

Genotype-Phenotype Analysis in Congenital Adrenal Hyperplasia due to P450 Oxidoreductase Deficiency

Krone, N., Reisch, N., Idkowiak, J., Dhir, V., Ivison, H. E., Hughes, B. A., Rose, I. T., O'Neil, D. M., Vijzelaar, R., Smith, M. J., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 163

Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5α-reductase, explaining the need for personalized glucocorticoid and androgen replacement

Chortis, V., Taylor, A. E., Schneider, P., Tomlinson, J. W., Hughes, B. A., O'Neil, D. M., Libé, R., Allolio, B., Bertagna, X., Bertherat, J., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism

Adrenal and Paraganglionic TumorsAdrenal Hormones and Disorders

Cited by 154

Increased 5α-Reductase Activity and Adrenocortical Drive in Women with Polycystic Ovary Syndrome

Vassiliadi, D. A., Barber, T. M., Hughes, B. A., McCarthy, M. I., Wass, J. A. H., Franks, S., Nightingale, P., Tomlinson, J. W., Arlt, W., & Stewart, P. M. (2009) · The Journal of Clinical Endocrinology & Metabolism

Ovarian function and disordersAdrenal Hormones and Disorders

Cited by 110

Reduced Glucocorticoid Production Rate, Decreased 5α-Reductase Activity, and Adipose Tissue Insulin Sensitization After Weight Loss

Tomlinson, J. W., Finney, J., Hughes, B. A., Hughes, S. V., & Stewart, P. M. (2008) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesAdrenal Hormones and Disorders

Cited by 91

PAPSS2 deficiency causes androgen excess via impaired DHEA sulfation–in vitro and in vivo studies in a family harboring two novel PAPSS2 mutations

Oostdijk, W., Idkowiak, J., Mueller, J. W., House, P. J., Taylor, A. E., O'Reilly, M. W., Hughes, B. A., de Vries, M. C., Kant, S. G., Santen, G. W. E., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 81

Modified release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia

Jones, C. M., Mallappa, A., Reisch, N., Nikolaou, N., Krone, N., Hughes, B. A., O’Neil, D. M., Whitaker, M. J., Tomlinson, J. W., Storbeck, K.-H., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 74

Prenatal diagnosis of congenital adrenal hyperplasia caused by P450 oxidoreductase deficiency

Reisch, N., Idkowiak, J., Hughes, B. A., Ivison, H. E., Abdul-Rahman, O. A., Hendon, L. G., Olney, A. H., Nielsen, S., Harrison, R., Blair, E. M., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 67

Cortisone-reductase deficiency associated with heterozygous mutations in 11β-hydroxysteroid dehydrogenase type 1

Lawson, A. J., Walker, E. A., Lavery, G. G., Bujalska, I. J., Hughes, B., Arlt, W., Stewart, P. M., & Ride, J. P. (2011) · Proceedings of the National Academy of Sciences

Adrenal Hormones and DisordersHormonal Regulation and Hypertension

Cited by 61

Human Δ4-3-oxosteroid 5β-reductase (AKR1D1) deficiency and steroid metabolism

Palermo, M., Marazzi, M. G., Hughes, B. A., Stewart, P. M., Clayton, P. T., & Shackleton, C. H. L. (2008) · Steroids

Adrenal Hormones and DisordersSteroid Chemistry and Biochemistry

Cited by 55

5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes

Nasiri, M., Nikolaou, N., Parajes, S., Krone, N. P., Valsamakis, G., Mastorakos, G., Hughes, B., Taylor, A., Bujalska, I. J., Gathercole, L. L., et al. (2015) · Endocrinology

Liver Disease Diagnosis and TreatmentEstrogen and related hormone effects

Cited by 50

Novel H6PDH mutations in two girls with premature adrenarche: ‘apparent’ and ‘true’ CRD can be differentiated by urinary steroid profiling

Lavery, G. G., Idkowiak, J., Sherlock, M., Bujalska, I., Ride, J. P., Saqib, K., Hartmann, M. F., Hughes, B., Wudy, S. A., De Schepper, J., et al. (2013) · European Journal of Endocrinology

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 50

17-Hydroxylase/C17, 20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites

Shackleton, C. H. L., Neres, M. S., Hughes, B. A., Stewart, P. M., & Kater, C. E. (2008) · Steroids

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 39

Reduced 11β-hydroxysteroid dehydrogenase type 1 activity in obese boys

Wiegand, S., Richardt, A., Remer, T., Wudy, S. A., Tomlinson, J. W., Hughes, B., Grüters, A., Stewart, P. M., Strasburger, C. J., & Quinkler, M. (2007) · European Journal of Endocrinology

Adrenal Hormones and DisordersHormonal Regulation and Hypertension

Cited by 37

Residual Adrenal Function in Autoimmune Addison's Disease: Improvement After Tetracosactide (ACTH1–24) Treatment

Gan, E. H., MacArthur, K., Mitchell, A. L., Hughes, B. A., Perros, P., Ball, S. G., James, R. A., Quinton, R., Chen, S., Furmaniak, J., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism

Adrenal Hormones and DisordersStress Responses and Cortisol

Cited by 36

Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype

Crowley, R. K., Hughes, B., Gray, J., McCarthy, T., Hughes, S., Shackleton, C. H. L., Crabtree, N., Nightingale, P., Stewart, P. M., & Tomlinson, J. W. (2014) · European Journal of Endocrinology

Hormonal Regulation and HypertensionAdipokines, Inflammation, and Metabolic Diseases

Cited by 26

Diminished 11β-Hydroxysteroid Dehydrogenase Type 2 Activity Is Associated With Decreased Weight and Weight Gain Across the First Year of Life

Rogers, S. L., Hughes, B. A., Jones, C. A., Freedman, L., Smart, K., Taylor, N., Stewart, P. M., Shackleton, C. H. L., Krone, N. P., Blissett, J., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism

Birth, Development, and HealthHormonal Regulation and Hypertension

Cited by 25