Wittrup, K. Dane

Biophysical properties of the clinical-stage antibody landscape

Jain, T., Sun, T., Durand, S., Hall, A., Houston, N. R., Nett, J. H., Sharkey, B., Bobrowicz, B., Caffry, I., Yu, Y., et al. (2017) · Proceedings of the National Academy of Sciences

Monoclonal and Polyclonal Antibodies ResearchProtein purification and stability

Cited by 629

Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity

Duong, E., Fessenden, T. B., Lutz, E., Dinter, T., Yim, L., Blatt, S., Bhutkar, A., Wittrup, K. D., & Spranger, S. (2022) · Immunity

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 372

Computational design of antibody-affinity improvement beyond in vivo maturation

Lippow, S. M., Wittrup, K. D., & Tidor, B. (2007) · Nature Biotechnology

Monoclonal and Polyclonal Antibodies ResearchProtein Structure and Dynamics

Cited by 342

Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity

Li, Y., Su, Z., Zhao, W., Zhang, X., Momin, N., Zhang, C., Wittrup, K. D., Dong, Y., Irvine, D. J., & Weiss, R. (2020) · Nature Cancer

Immunotherapy and Immune ResponsesRNA Interference and Gene Delivery

Cited by 233

An engineered protein antagonist of K-Ras/B-Raf interaction

Kauke, M. J., Traxlmayr, M. W., Parker, J. A., Kiefer, J. D., Knihtila, R., McGee, J., Verdine, G., Mattos, C., & Wittrup, K. D. (2017) · Scientific Reports

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 64