Dharmalingam, Gopuraja

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,278

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Herranz, N., Gallage, S., Mellone, M., Wuestefeld, T., Klotz, S., Hanley, C. J., Raguz, S., Acosta, J. C., Innes, A. J., Banito, A., et al. (2015) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 788

Cardiac glycosides are broad-spectrum senolytics

Guerrero, A., Herranz, N., Sun, B., Wagner, V., Gallage, S., Guiho, R., Wolter, K., Pombo, J., Irvine, E. E., Innes, A. J., et al. (2019) · Nature Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 359

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Georgilis, A., Klotz, S., Hanley, C. J., Herranz, N., Weirich, B., Morancho, B., Leote, A. C., D'Artista, L., Gallage, S., Seehawer, M., et al. (2018) · Cancer Cell

Telomeres, Telomerase, and SenescenceRNA Research and Splicing

Cited by 237

Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation

Cuartero, S., Weiss, F. D., Dharmalingam, G., Guo, Y., Ing-Simmons, E., Masella, S., Robles-Rebollo, I., Xiao, X., Wang, Y.-F., Barozzi, I., et al. (2018) · Nature Immunology

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 210

Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence

Aarts, M., Georgilis, A., Beniazza, M., Beolchi, P., Banito, A., Carroll, T., Kulisic, M., Kaemena, D. F., Dharmalingam, G., Martin, N., et al. (2017) · Genes & Development

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 64

XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence

Innes, A. J., Sun, B., Wagner, V., Brookes, S., McHugh, D., Pombo, J., Porreca, R. M., Dharmalingam, G., Vernia, S., Zuber, J., et al. (2021) · Genes & Development

Telomeres, Telomerase, and SenescenceNuclear Structure and Function

Cited by 30