Sugiyama, Tomomi

Theanine, a specific glutamate derivative in green tea, reduces the adverse reactions of doxorubicin by changing the glutathione level

Sugiyama, T., & Sadzuka, Y. (2004) · Cancer Letters

Chemotherapy-induced organ toxicity mitigationChemotherapy-induced cardiotoxicity and mitigation

Cited by 95

The effects of theanine, as a novel biochemical modulator, on the antitumor activity of adriamycin

Sadzuka, Y., Sugiyama, T., Miyagishima, A., Nozawa, Y., & Hirota, S. (1996) · Cancer Letters

Drug Transport and Resistance MechanismsCancer therapeutics and mechanisms

Cited by 68

Enhancement of the activity of doxorubicin by inhibition of glutamate transporter

Sadzuka, Y., Sugiyama, T., Suzuki, T., & Sonobe, T. (2001) · Toxicology Letters

Drug Transport and Resistance MechanismsGlutathione Transferases and Polymorphisms

Cited by 52

Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin

Sugiyama, T., Sadzuka, Y., Tanaka, K., & Sonobe, T. (2001) · Toxicology Letters

Drug Transport and Resistance MechanismsAmino Acid Enzymes and Metabolism

Cited by 47

Membrane transport and antitumor activity of pirarubicin, and comparison with those of doxorubicin

Sugiyama, T., Sadzuka, Y., Nagasawa, K., Ohnishi, N., Yokoyama, T., & Sonobe, T. (1999) · Japanese Journal of Cancer Research

Drug Transport and Resistance MechanismsCancer therapeutics and mechanisms

Cited by 40

Effects of theanine on alcohol metabolism and hepatic toxicity

Sadzuka, Y., Inoue, C., Hirooka, S., Sugiyama, T., Umegaki, K., & Sonobe, T. (2005) · Biological and Pharmaceutical Bulletin

Alcohol Consumption and Health EffectsDrug-Induced Hepatotoxicity and Protection

Cited by 29

Efficacy of theanine is connected with theanine metabolism by any enzyme, not only drug metabolizing enzymes.

Sadzuka, Y., Sugiyama, T., Nagamine, M., Umegaki, K., & Sonobe, T. (2006) · Food and Chemical Toxicology

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 10