Coe, Jotham W.

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

Coe, J. W., Brooks, P. R., Vetelino, M. G., Wirtz, M. C., Arnold, E. P., Huang, J., Sands, S. B., Davis, T. I., Lebel, L. A., Fox, C. B., et al. (2005) · Journal of Medicinal Chemistry

Nicotinic Acetylcholine Receptors StudySmoking Behavior and Cessation

Cited by 930

Delineating the role of cooperativity in the design of potent PROTACs for BTK

Zorba, A., Nguyen, C., Xu, Y., Starr, J., Borzilleri, K., Smith, J., Zhu, H., Farley, K. A., Ding, W., Schiemer, J., et al. (2018) · Proceedings of the National Academy of Sciences

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 419

Rationale, pharmacology and clinical efficacy of partial agonists of α4β2 nACh receptors for smoking cessation

Rollema, H., Coe, J. W., Chambers, L. K., Hurst, R. S., Stahl, S. M., & Williams, K. E. (2007) · Trends in Pharmacological Sciences

Smoking Behavior and CessationNicotinic Acetylcholine Receptors Study

Cited by 400

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2 S,5 R)-5-((7 H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans

Thorarensen, A., Dowty, M. E., Banker, M. E., Juba, B., Jussif, J., Lin, T., Vincent, F., Czerwinski, R. M., Casimiro-Garcia, A., Unwalla, R., et al. (2017) · Journal of Medicinal Chemistry

Cytokine Signaling Pathways and InteractionsHeterocyclic Compound Synthesis and Bioactivity

Cited by 176

Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect

Rollema, H., Guanowsky, V., Mineur, Y. S., Shrikhande, A., Coe, J. W., Seymour, P. A., & Picciotto, M. R. (2009) · European Journal of Pharmacology

Treatment of Major DepressionNicotinic Acetylcholine Receptors Study

Cited by 87

α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties

Mineur, Y. S., Einstein, E. B., Seymour, P. A., Coe, J. W., O'Neill, B. T., Rollema, H., & Picciotto, M. R. (2011) · Behavioural Pharmacology

Nicotinic Acetylcholine Receptors StudyTreatment of Major Depression

Cited by 49