Hughes, Michelle A.

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

Dickens, L. S., Boyd, R. S., Jukes-Jones, R., Hughes, M. A., Robinson, G. L., Fairall, L., Schwabe, J. W. R., Cain, K., & MacFarlane, M. (2012) · Molecular Cell

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 349

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

Hughes, M. A., Powley, I. R., Jukes-Jones, R., Horn, S., Feoktistova, M., Fairall, L., Schwabe, J. W. R., Leverkus, M., Cain, K., & MacFarlane, M. (2016) · Molecular Cell

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 257

The ‘complexities’ of life and death: Death receptor signalling platforms

Dickens, L. S., Powley, I. R., Hughes, M. A., & MacFarlane, M. (2012) · Experimental Cell Research

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 208

Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival

Horn, S., Hughes, M. A., Schilling, R., Sticht, C., Tenev, T., Ploesser, M., Meier, P., Sprick, M. R., MacFarlane, M., & Leverkus, M. (2017) · Cell Reports

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 119

Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex

Powley, I. R., Hughes, M. A., Cain, K., & MacFarlane, M. (2016) · Oncogene

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 54