Tlsty, Thea D.

Integrative analysis of 111 reference human epigenomes

Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 6,368

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer

Cancer Cells and MetastasisTGF-β signaling in diseases

Cited by 3,863

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Shah, S. P., Roth, A., Goya, R., Oloumi, A., Ha, G., Zhao, Y., Turashvili, G., Ding, J., Tse, K., Haffari, G., et al. (2012) · Nature

Cancer Genomics and DiagnosticsBreast Cancer Treatment Studies

Cited by 1,967

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

Romanov, S. R., Kozakiewicz, B. K., Holst, C. R., Stampfer, M. R., Haupt, L. M., & Tlsty, T. D. (2001) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 560

Know thy neighbor: stromal cells can contribute oncogenic signals

Tlsty, T. D., & Hein, P. W. (2001) · Current Opinion in Genetics & Development

Cancer Cells and MetastasisTGF-β signaling in diseases

Cited by 425

Abrogated Response to Cellular Stress Identifies DCIS Associated with Subsequent Tumor Events and Defines Basal-like Breast Tumors

Gauthier, M. L., Berman, H. K., Miller, C., Kozakeiwicz, K., Chew, K., Moore, D., Rabban, J., Chen, Y. Y., Kerlikowske, K., & Tlsty, T. D. (2007) · Cancer Cell

Breast Cancer Treatment StudiesBreast Lesions and Carcinomas

Cited by 214

CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues

DeFilippis, R. A., Chang, H., Dumont, N., Rabban, J. T., Chen, Y.-Y., Fontenay, G. V., Berman, H. K., Gauthier, M. L., Zhao, J., Hu, D., et al. (2012) · Cancer Discovery

Digital Radiography and Breast ImagingCancer, Lipids, and Metabolism

Cited by 212

Breast Fibroblasts Modulate Early Dissemination, Tumorigenesis, and Metastasis through Alteration of Extracellular Matrix Characteristics

Dumont, N., Liu, B., DeFilippis, R. A., Chang, H., Rabban, J. T., Karnezis, A. N., Tjoe, J. A., Marx, J., Parvin, B., & Tlsty, T. D. (2013) · Neoplasia

Cancer Cells and MetastasisCellular Mechanics and Interactions

Cited by 192

Primary Cilia Regulate Branching Morphogenesis during Mammary Gland Development

McDermott, K. M., Liu, B. Y., Tlsty, T. D., & Pazour, G. J. (2010) · Current Biology

Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances

Cited by 100

p16INK4a modulates p53 in primary human mammary epithelial cells.

Zhang, J., Pickering, C. R., Holst, C. R., Gauthier, M. L., & Tlsty, T. D. (2006) · Cancer Research

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 60

Genetic and Epigenetic Changes in Mammary Epithelial Cells Identify a Subpopulation of Cells Involved in Early Carcinogenesis

BERMAN, H., ZHANG, J., CRAWFORD, Y. G., GAUTHIER, M. L., FORDYCE, C. A., McDERMOTT, K. M., SIGAROUDINIA, M., KOZAKIEWICZ, K., & TLSTY, T. D. (2005) · Cold Spring Harbor Symposia on Quantitative Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 51

Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes

Fordyce, C. A., Patten, K. T., Fessenden, T. B., DeFilippis, R., Hwang, E. S., Zhao, J., & Tlsty, T. D. (2012) · Breast Cancer Research

TGF-β signaling in diseasesTelomeres, Telomerase, and Senescence

Cited by 50

DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions

Fordyce, C., Fessenden, T., Pickering, C., Jung, J., Singla, V., Berman, H., & Tlsty, T. (2010) · Cancer Prevention Research

Inflammatory mediators and NSAID effectsTelomeres, Telomerase, and Senescence

Cited by 41