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Topical Vitamin A Acid in Acne Vulgaris
Abstract
The therapeutic effectiveness of four local forms of treatment was compared in acne vulgaris: (a) sulfur-resorcinol; (b) benzoyl peroxide; (c) vitamin A acid; and, (d) an inert vehicle. The method of assessment was counting all the lesions on one side of the face at weekly intervals. The order of increasing therapeutic efficacy was: vehicle, sulfur-resorcinol, benzoyl peroxide, and vitamin A acid. Vitamin A acid increased the rate of production of loose horny cells in the follicular canal, thus preventing formation of comedones and unseating existing ones. The treatment frequently produces a worsening of the clinical picture during the initial phase of therapy. It is palliative, not curative; relapses occasionally occur when treatment is stopped.
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Citations
Cited by
Gollnick, H., Cunliffe, W., Berson, D., Dreno, B., Finlay, A., Leyden, J. J., Shalita, A. R., & Thiboutot, D. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.618 · Cited by 817
Topical tretinoin for photoaged skin
Kligman, A. M., Grove, G. L., Hirose, R., & Leyden, J. J. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70242-9 · Cited by 620
Self-citationNiosomes as carriers for tretinoin
Manconi, M., Sinico, C., Valenti, D., Lai, F., & Fadda, A. M. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.11.045 · Cited by 267
Studies on the Mechanism of Action of Topical Benzoyl Peroxide and Vitamin A Acid in Acne Vulgaris
Fulton, J. E., Farzad‐Bakshandeh, A., & Bradley, S. (1974) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.1974.tb00628.x · Cited by 134
Self-citationThe treatment of visible signs of senescence: the Asian experience
GOH, S. H. (1990) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1990.tb16134.x · Cited by 94
Metadata
- Authors
- Kligman, A. M.
- Venue
- Archives of Dermatology
- Publisher
- American Medical Association (AMA)
- Published
- 1969-04-01
- Volume
- 99
- Issue
- 4
- Pages
- 469
- ISSN
- 0003-987X (ISSN-L)
- OpenAlex
- W2066260473
- Cited by
- 331
- References
- 0
- FWCI
- 52.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kligman, A. M. (1969). Topical Vitamin A Acid in Acne Vulgaris. Archives of Dermatology. https://doi.org/10.1001/archderm.1969.01610220097017
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
