Association of variants in DISC1 with psychosis-related traits in a large population cohort
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CONTEXT: There is an abundance of data from human genetic studies and animal models that implies a role for the disrupted in schizophrenia 1 gene (DISC1) in the etiology of schizophrenia and other major mental illnesses. OBJECTIVE: To study the effect of previously identified risk alleles of DISC1 on quantitative intermediate phenotypes for psychosis in an unselected population. DESIGN: We examined 41 single-nucleotide polymorphisms within DISC1 and performed tests of association with 4 quantitative phenotypes. SETTING: Academic research. PARTICIPANTS: Individuals from an unselected birth cohort in Finland. Originally, everyone born in the catchment area in 1966 (N = 12 058) was included in the study. Of these, 4651 (38.6%) attended the 31-year follow-up and could be included in the study. MAIN OUTCOME MEASURES: Scores on 4 psychometric instruments selected to function as proxies for positive and negative aspects of psychotic disorders, including the Perceptual Aberration Scale, Revised Social Anhedonia Scale, Revised Physical Anhedonia Scale, and Schizoidia Scale by Golden and Meehl. RESULTS: Carriers of the minor allele of marker rs821577 had significantly higher scores on social anhedonia (P < .001). The minor allele of marker rs821633 was strongly associated with lower scores on social anhedonia when analyzed dependent on the absence of the minor alleles of markers rs1538979 and rs821577 (P < .001). CONCLUSIONS: Variants in DISC1 affect the level of social anhedonia, a cardinal symptom of schizophrenia in the general population. DISC1 might be more central to human psychological functioning than previously thought, as it seems to affect the degree to which people enjoy social interactions.
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Single nucleotide polymorphisms in genes implicated in neurodevelopment are associated with social anhedonia along the psychosis continuum.
“Similarly, single nucleotide polymorphisms (SNPs) in genes implicated in neurodevelopment have been associated with social anhedonia along the psychosis continuum (155, 156).”
From A transdiagnostic perspective on social anhedonia (2019) · cites this paper as [156]
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References 49 · Cited by 57
Research works printed but not linked: 2
- [26]Chapman LJ Chapman JP Kwapil TR Eckblad M Zinser MC Putatively psychosisprone subjects 10 years later J Abnorm Psychol 1994 103 2 171 183 8040487
- [43]Hennah W Tuulio-Henriksson A Paunio T Ekelund J Varilo T Partonen T Cannon TD Lonnqvist J Peltonen L A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia Mol Psychiatry 2005 10 12 1097 1103 16103888
- Authors
- Tomppo, L., Hennah, W., Miettunen, J., Järvelin, M.-R., Veijola, J., Ripatti, S., Lahermo, P., Lichtermann, D., Peltonen, L., & Ekelund, J.
- Affiliations
- University of Helsinki (FI)
- ORCID
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2009-02-01
- Volume
- 66
- Issue
- 2
- Pages
- 134
- ISSN
- 0003-990X (ISSN-L)
- PMC
- PMC2704396
- OpenAlex
- W2142758088
- Cited by
- 57
- References
- 49
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 11
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (089061)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- DISC1, schizophrenia, psychosis, social anhedonia, single nucleotide polymorphisms, risk alleles, endophenotypes, birth cohort, genetic association
- MeSH terms
- Adult, Affective Symptoms, Alleles, Female, Finland, Follow-Up Studies, Genotype, Genetic Carrier Screening, Humans, Male, Nerve Tissue Proteins, Psychiatric Status Rating Scales, Psychotic Disorders, Schizophrenia, Schizophrenic Psychology, Social Behavior, Cohort Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
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