The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Distinguishing between major depressive disorder and obsessive–compulsive disorder in children by measuring regional cortical thickness
Open accessAbstract
CONTEXT: Cortical abnormalities have been noted in previous studies of major depressive disorder (MDD). OBJECTIVE: To hypothesize differences in regional cortical thickness among children with MDD, children with obsessive-compulsive disorder (OCD), and healthy controls. DESIGN: Cross-sectional study of groups. SETTING: Children's Hospital of Michigan in Detroit. PARTICIPANTS: A total of 24 psychotropic drug-naive pediatric patients with MDD (9 boys and 15 girls), 24 psychotropic drug-naive pediatric outpatients with OCD (8 boys and 16 girls), and 30 healthy controls (10 boys and 20 girls). INTERVENTION: Magnetic resonance imaging. MAIN OUTCOME MEASURE: Cortical thickness. RESULTS: In the right hemisphere of the brain, the pericalcarine gyrus was thinner in patients with MDD than in outpatients with OCD (P = .002) or healthy controls (P = .04), the postcentral gyrus was thinner in patients with MDD than in outpatients with OCD (P = .002) or healthy controls (P = .02), and the superior parietal gyrus was thinner in patients with MDD than in outpatients with OCD (P = .008) or healthy controls (P = .03). The outpatients with OCD and the healthy controls did not differ in these regions of the brain. The temporal pole was thicker in patients with MDD than in outpatients with OCD (P < .001) or healthy controls (P = .01), both of which groups did not differ in temporal pole thickness. The cuneus was thinner in patients with MDD than in outpatients with OCD (P = .008), but it did not differ from that in healthy controls. In the left hemisphere, the supramarginal gyrus was thinner in both patients with MDD (P = .04) and outpatients with OCD (P = .01) than in healthy controls, and the temporal pole was thicker in patients with MDD than in both healthy controls and outpatients with OCD (P < .001). CONCLUSIONS: To our knowledge, this is the first study to explore cortical thickness in pediatric patients with MDD. Although differences in some regions of the brain would be expected given neurobiological models of MDD, our study highlights some unexpected regions (ie, supramarginal and superior parietal gyri) that merit further investigation. These results underscore the need to expand exploration beyond the frontal-limbic circuit.
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“This analysis also showed associations between depression scores and superior parietal lobule and parahippocampal gyrus activity, two regions that have shown depression related phenotypes in previous studies (Fallucca et al., 2011; Milne et al., 2012).”
From Reduced nucleus accumbens reactivity and adolescent depression following early-life stress (2013) · cites this paper as Fallucca et al., 2011
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Desikan, R. S., Ségonne, F., Fischl, B., Quinn, B. T., Dickerson, B. C., Blacker, D., Buckner, R. L., Dale, A. M., Maguire, R. P., Hyman, B. T., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.021 · Cited by 13,324
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The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455
Cortical Surface-Based Analysis
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Development of a Rating Scale for Primary Depressive Illness
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Cortical Surface-Based Analysis
Fischl, B., Sereno, M. I., & Dale, A. M. (1999) · NeuroImage · doi:10.1006/nimg.1998.0396 · Cited by 6,147
Measuring the thickness of the human cerebral cortex from magnetic resonance images
Fischl, B. R., & Dale, A. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200033797 · Cited by 5,995
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Fischl, B. R. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg087 · Cited by 4,208
Unbiased average age-appropriate atlases for pediatric studies
Fonov, V., Evans, A. C., Botteron, K., Almli, C. R., McKinstry, R. C., & Collins, D. L. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.07.033 · Cited by 2,290
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for the ENIGMA-Major Depressive Disorder Working Group, Schmaal, L., Hibar, D. P., Sämann, P. G., Hall, G. B., Baune, B. T., Jahanshad, N., Cheung, J. W., van Erp, T. G. M., Bos, D., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.60 · Cited by 1,330
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Reduced nucleus accumbens reactivity and adolescent depression following early-life stress
Goff, B., Gee, D. G., Telzer, E. H., Humphreys, K. L., Gabard-Durnam, L., Flannery, J., & Tottenham, N. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.010 · Cited by 234
Sandman, C. A., Buss, C., Head, K., & Davis, E. P. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.025 · Cited by 219
Metadata
- Authors
- Fallucca, E., MacMaster, F. P., Haddad, J., Easter, P., Dick, R., May, G., Stanley, J. A., Rix, C., & Rosenberg, D. R.
- Affiliations
- Wayne State University (US)
- University of Calgary (CA)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2011-05-02
- Volume
- 68
- Issue
- 5
- Pages
- 527
- ISSN
- 0003-990X (ISSN-L)
- PMC
- PMC4777351
- OpenAlex
- W1994823296
- Cited by
- 113
- References
- 59
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 50 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 3 · 2012: 8
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K24MH002037, R01MH065122, R01MH059299)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- major depressive disorder, obsessive-compulsive disorder, childhood depression, cortical thickness, brain structure, superior parietal gyrus, supramarginal gyrus, temporal pole, cuneus, right hemisphere, differential diagnosis, neuroimaging biomarkers, magnetic resonance imaging, cortical thinning, cortical thickening
- MeSH terms
- Adolescent, Brain Mapping, Cerebral Cortex, Child, Cross-Sectional Studies, Major Depressive Disorder, Diagnosis, Differential, Dominance, Cerebral, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Obsessive-Compulsive Disorder, Organ Size, Comorbidity, Genetic Predisposition to Disease
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