The DOI matches its OpenAlex record; 1 of the 1 references it cites were found in a registry or an index.
The syndrome of essential hypertension and suppressed plasma renin activity. Normalization of blood pressure with spironolactone
Abstract
Because amino-glutethimide, an inhibitor of steroid synthesis, lowers the blood pressure of patients with essential hypertension and suppressed renin activity, the present double-blind study was designed to assess the effect of the mineralocorticoid antagonist, spironolactone, on blood pressure in such patients. Twenty-three of 24 patients with suppressed renin activity responded to spironolactone, 400 mg/day for six weeks. Average decrease in mean blood pressure was 20 mm Hg. There was no response to placebo. A control group of 18 patients with essential hypertension and normal renin activity showed no significant change in blood pressure in response to spironolactone or placebo. Fourteen spironolactone-responsive patients were normotensive when maintained on doses of 100 to 200 mg/day. This study supports the concept that the syndrome of essential hypertension with suppressed renin activity is related to mineralocorticoid secretion.
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Cites
17-Hydroxylation deficiency in man
Biglieri, E. G., Herron, M. A., & Brust, N. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105499 · Cited by 561
Cited by
Effects of Caffeine on Plasma Renin Activity, Catecholamines and Blood Pressure
Robertson, D., Frölich, J. C., Carr, R. K., Watson, J. T., Hollifield, J. W., Shand, D. G., & Oates, J. A. (1978) · New England Journal of Medicine · doi:10.1056/nejm197801262980403 · Cited by 757
The Unrecognized Prevalence of Primary Aldosteronism: A Cross-sectional Study
Brown, J. M., Siddiqui, M., Calhoun, D. A., Carey, R. M., Hopkins, P. N., Williams, G. H., & Vaidya, A. (2020) · Annals of Internal Medicine · doi:10.7326/m20-0065 · Cited by 649
Self-citationTolerance to the humoral and hemodynamic effects of caffeine in man.
Robertson, D., Wade, D., Workman, R., Woosley, R. L., & Oates, J. A. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110124 · Cited by 501
Laragh, J. H. (1973) · The American Journal of Medicine · doi:10.1016/0002-9343(73)90128-9 · Cited by 483
Primary Aldosteronism: Diagnosis, Localization, and Treatment
WEINBERGER, M. H., GRIM, C. E., HOLLIFIELD, J. W., KEM, D. C., GANGULY, A., KRAMER, N. J., YUNE, H. Y., WELLMAN, H., & DONOHUE, J. P. (1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-90-3-386 · Cited by 352
Metadata
- Authors
- Carey, R. M.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association
- Published
- 1972-12-01
- Volume
- 130
- Issue
- 6
- Pages
- 849-854
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W4252126843
- Cited by
- 173
- References
- 1
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carey, R. M. (1972). The syndrome of essential hypertension and suppressed plasma renin activity. Normalization of blood pressure with spironolactone. Archives of Internal Medicine. https://doi.org/10.1001/archinte.130.6.849
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
