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Sampling Variability on Percutaneous Liver Biopsy
Abstract
Sampling variability of liver biopsy was determined in three consecutive biopsy specimens obtained from each of 118 patients immediately prior to autopsy. No sampling variability was found for fatty liver, alcoholic hepatitis, nonspecific hepatitis, fulminant hepatitis, leukemic infiltrate, and venous congestion. Cirrhosis was diagnosed in 80% of cases at the first biopsy but in all cases after three biopsies. Chronic aggressive and chronic persistent hepatitis were diagnosed correctly in two of three cases each at the first biopsy, and in all cases after three biopsies. Metastatic carcinoma was detected in 46% of cases at the first biopsy and in 69% after three biopsies. Granulomas were missed once on the first biopsy, but found on a subsequent biopsy. The amounts of fat and fibrosis in the biopsy specimens often were not representative of the amounts present at autopsy.
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Cited by
Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease
Ratziu, V., Charlotte, F., Heurtier, A., Gombert, S., Giral, P., Bruckert, E., Grimaldi, A., Capron, F., & Poynard, T. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.084 · Cited by 2,106
Schuppan, D., & Afdhal, N. H. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60383-9 · Cited by 2,089
Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis
Millonig, G., Reimann, F. M., Friedrich, S., Fonouni, H., Mehrabi, A., Büchler, M. W., Seitz, H. K., & Mueller, S. (2008) · Hepatology · doi:10.1002/hep.22577 · Cited by 599
Liver stiffness: a novel parameter for the diagnosis of liver disease
Mueller, S. (2010) · Hepatic Medicine: Evidence and Research · doi:10.2147/hmer.s7394 · Cited by 434
Transient elastography to assess hepatic fibrosis in primary biliary cirrhosis
GÓMEZ‐DOMINGUEZ, E., MENDOZA, J., GARCÍA‐BUEY, L., TRAPERO, M., GISBERT, J. P., JONES, E. A., & MORENO‐OTERO, R. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03585.x · Cited by 84
Metadata
- Authors
- Abdi, W.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association
- Published
- 1979-06-01
- Volume
- 139
- Issue
- 6
- Pages
- 667-667
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2092607950
- Cited by
- 274
- References
- 0
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
