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Association Between Active Wegener's Granulomatosis and Anticytoplasmic Antibodies
Abstract
Autoantibodies reacting with the cytoplasm of granulocytes and monocytes (anticytoplasmic antibodies [ACPAs]) were found in 42 of 45 patients with active Wegener's granulomatosis (WG) (sensitivity, 93%). Specificity was tested in selected groups of patients with closely related diseases. Of 58 patients without a diagnosis of WG, 2 had ACPAs (specificity, 97%). The significance of ACPA titration for assessing or predicting disease activity was evaluated in a 16-month prospective study of 35 patients with WG. Seventeen relapses were observed and all were preceded by a significant rise of the ACPA titer. Anticytoplasmic antibodies are a specific and sensitive marker for active WG; a rising titer is a sensitive marker for the development of a relapse.
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Cited by
Falk, R. J., Hogan, S., Carey, T. S., Jennette, J. C., & The Glomerular Disease Collaborative Network (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-9-656 · Cited by 391
Lo, S. K., Fleming, K. A., & Chapman, R. W. (1994) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80604-x · Cited by 50
Metadata
- Authors
- Tervaert, J. W. C.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association
- Published
- 1989-11-01
- Volume
- 149
- Issue
- 11
- Pages
- 2461-2461
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2004860183
- Cited by
- 517
- References
- 0
- FWCI
- 29.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Association Between Active Wegener's Granulomatosis and Anticytoplasmic Antibodies. https://app.cochat.ai/papers/10.1001/archinte.149.11.2461
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- Tervaert, J. W. C. (1989). Association Between Active Wegener's Granulomatosis and Anticytoplasmic Antibodies. Archives of Internal Medicine. https://doi.org/10.1001/archinte.149.11.2461
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
