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Cited by 855

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Prospective Study of Body Mass Index, Weight Change, and Risk of Adult-onset Asthma in Women

Camargo, Carlos A., Weiss, Scott T., Zhang, Shumin, Willett, Walter C., Speizer, Frank E.·1999·Archives of Internal Medicine

Abstract

BACKGROUND: Obesity and asthma are common disorders, and their prevalence rates continue to rise. Although individuals with asthma may gain weight as a result of activity limitations, the relationship between body mass index (BMI), which is calculated as weight in kilograms divided by the square of height in meters, and risk of developing asthma is not known. METHODS: We performed a prospective cohort study of female US registered nurses in the Nurses' Health Study II. In 1991, after excluding women who died with probable asthma or with incomplete data, there were 85911 participants, aged 26 to 46 years. The main outcome measure was self-report of physician-diagnosed asthma with recent use of an asthma medication. RESULTS: From 1991 to 1995, we identified 1596 incident cases of asthma. In a multivariate model controlling for 9 potential confounding factors (including age, race, smoking, physical activity, and energy intake), the relative risks of asthma for 6 increasing categories of BMI in 1991 were 0.9, 1.0 (reference), 1.1, 1.6, 1.7, and 2.7 (P for trend <.001). Stronger associations were found using stricter definitions for asthma, and the finding was present in a variety of subgroups. In analyses controlling for the same variables, as well as BMI at age 18, women who gained weight after age 18 were at significantly increased risk of developing asthma during the 4-year follow-up period (P for trend <.001). CONCLUSIONS: The BMI has a strong, independent, and positive association with risk of adult-onset asthma. The increasing prevalence of obesity in developed nations may help explain concomitant increases in asthma prevalence.

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Metadata

Authors
Camargo, C. A., Weiss, S. T., Zhang, S., Willett, W. C., & Speizer, F. E.
Venue
Archives of Internal Medicine
Published
1999-11-22
Volume
159
Issue
21
Pages
2582
ISSN
0003-9926 (ISSN-L)
OpenAlex
W2061376514
Cited by
855
References
44
FWCI
11.24
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Prospective Study of Body Mass Index, Weight Change, and Risk of Adult-onset Asthma in Women. https://app.cochat.ai/papers/10.1001/archinte.159.21.2582
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Camargo, C. A., Weiss, S. T., Zhang, S., Willett, W. C., & Speizer, F. E. (1999). Prospective Study of Body Mass Index, Weight Change, and Risk of Adult-onset Asthma in Women. Archives of Internal Medicine. https://doi.org/10.1001/archinte.159.21.2582

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