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Cited by 453Obstructive Sleep Apnea ResearchSleep and related disordersDiabetes Management and Research

The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.

Type 2 Diabetes, Glycemic Control, and Continuous Positive Airway Pressure in Obstructive Sleep Apnea

Babu, Ambika R., Herdegen, James, Fogelfeld, Leon, Shott, Susan, Mazzone, Theodore·2005·Archives of Internal Medicine
DOI 10.1001/archinte.165.4.447
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Abstract

BACKGROUND: Sleep-disordered breathing (SDB) is a prevalent condition associated with significant comorbidities, including hypertension, obesity, cardiovascular disease, and insulin resistance. It has been previously shown that the severity of insulin resistance is related to the severity of SDB. METHODS: Using a 72-hour continuous glucose monitoring system, we studied changes in interstitial glucose levels and measured hemoglobin A1c levels in 25 patients with type 2 diabetes mellitus before and after continuous positive airway pressure (CPAP) treatment for SDB. RESULTS: With a mean +/- SD CPAP treatment period of 83 +/- 50 days, the mean +/- SD 1-hour postprandial glucose values were significantly reduced for breakfast (191 +/- 68 mg/dL to 130 +/- 41 mg/dL [10.6 +/- 3.8 mmol/L to 7.2 +/- 2.3 mmol/L]), lunch (196 +/- 70 mg/dL to 138 +/- 49 mg/dL [10.9 +/- 3.9 mmol/L to 7.7 +/- 2.7 mmol/L]), and dinner (199 +/- 66 mg/dL to 137 +/- 48 mg/dL [11.0 +/- 3.7 mmol/L to 7.6 +/- 2.7 mmol/L]). In the 17 patients with a baseline hemoglobin A1c level greater than 7%, there was a significant reduction in hemoglobin A1c level (9.2% +/- 2.0% to 8.6% +/- 1.8%). Furthermore, in subjects who used CPAP for more than 4 h/d, the reduction in hemoglobin A1c level was significantly correlated with days of CPAP use. There was no such correlation in subjects who used CPAP for 4 h/d or less. CONCLUSIONS: These findings suggest that SDB is pathophysiologically related to impaired glucose homeostasis, and that CPAP can be an important therapeutic approach for diabetic patients with SDB.

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Metadata

Authors
Babu, A. R., Herdegen, J., Fogelfeld, L., Shott, S., & Mazzone, T.
Affiliations
Rush University Medical Center (US)
ORCID
Fogelfeld, Leon
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2005-02-28
Volume
165
Issue
4
Pages
447
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.165.4.447
OpenAlex
W2103628919
Cited by
453
References
41
Citations by year
2026: 2 · 2025: 12 · 2024: 4 · 2023: 7 · 2022: 13 · 2021: 7 · 2020: 15 · 2019: 12 · 2018: 18 · 2017: 16 · 2016: 21 · 2015: 33 · 2014: 31 · 2013: 22 · 2012: 37
FWCI
21.57
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
type 2 diabetes, obstructive sleep apnea, sleep-disordered breathing, continuous positive airway pressure, glycemic control, HbA1c, postprandial blood glucose, insulin resistance, glucose homeostasis
MeSH terms
Adult, Blood Glucose, Circadian Rhythm, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Prospective Studies, Surveys and Questionnaires, Polysomnography, Sleep Apnea, Obstructive, Glycemic Index, Continuous Positive Airway Pressure

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