Cited by 380Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudySubstance Abuse Treatment and Outcomes

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Efficacy and Safety of the Novel Selective Nicotinic Acetylcholine Receptor Partial Agonist, Varenicline, for Smoking Cessation

Oncken, Cheryl·2006·Archives of Internal Medicine

Open this paper in CoChat — free account

Abstract

BACKGROUND: The selective nicotinic acetylcholine receptor partial agonist, varenicline tartrate, represents a novel type of therapy for smoking cessation. This study evaluated the efficacy, safety, and tolerability of 4 varenicline dose regimens, 2 with progressive dosing over the first week (eg, titrated) and 2 with a fixed dosing schedule (eg, non-titrated), for promoting smoking cessation. METHODS: This multicenter, double-blind, placebo-controlled study randomized healthy smokers (aged 18-65 years) to varenicline tartrate, 0.5 mg twice daily nontitrated (n = 129), 0.5 mg twice daily titrated (n = 130), 1.0 mg twice daily nontitrated (n = 129), 1.0 mg twice daily titrated (n = 130), or placebo (n = 129) for 12 weeks to aid in smoking cessation. A 40-week follow-up period assessed long-term efficacy. The primary efficacy measures were the carbon monoxide-confirmed 4-week continuous quit rates by pooled dosage group for weeks 4 through 7 and 9 through 12 and the continuous abstinence rates for weeks 9 through 52. RESULTS: Weeks 9 through 12 continuous quit rates were greater in the 1.0-mg group (49.4%) and the 0.5-mg group (44.0%) vs placebo (11.6%; P<.001 vs both doses). Weeks 9 through 52 abstinence rates were greater in the 1.0-mg group (22.4%; P<.001) and the 0.5-mg group (18.5%; P<.001) vs placebo (3.9%). Varenicline was generally well tolerated, with nausea occurring in 16% to 42% of varenicline-treated subjects. Reports of nausea were lower for the titrated vs nontitrated dosing and infrequently led to medication discontinuation. CONCLUSION: Varenicline tartrate, 0.5 mg and 1.0 mg twice daily, is efficacious for smoking cessation.

Integrity signals

Registry

Crossref · 10.1001/archinte.166.15.1571

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
HEATHERTON, T. F., KOZLOWSKI, L. T., FRECKER, R. C., & FAGERSTROM, K. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01879.x · Cited by 10,738
Signs and Symptoms of Tobacco Withdrawal
Hughes, J. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800030107013 · Cited by 1,669
Estimates of global mortality attributable to smoking in 2000
Ezzati, M., & Lopez, A. D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14338-3 · Cited by 1,247
Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation
Coe, J. W., Brooks, P. R., Vetelino, M. G., Wirtz, M. C., Arnold, E. P., Huang, J., Sands, S. B., Davis, T. I., Lebel, L. A., Fox, C. B., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050069n · Cited by 930
Treating Tobacco Use and Dependence: An Introduction to the Us Public Health Service Clinical Practice Guideline
Fiore, M. (2000) · Respiratory care · doi:10.1177/002013240004501006 · Cited by 773
Tobacco or Health: A Global Status ReportTobacco or Health: A Global Status ReportWorld Health Organization, Geneva1997 ISBN 92 4 1561 84X
Schultz, H. (1998) · Annals of Saudi Medicine · doi:10.5144/0256-4947.1998.195 · Cited by 430
Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebo-controlled, randomised trial
Tashkin, D., Kanner, R. E., Bailey, W. C., Buist, S. A., ANDERSON, P. J., Nides, Gonzales, D. H., Dozier, G., Patel, M., & Jamerson, B. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04724-3 · Cited by 412
Transdermal Nicotine for Smoking Cessation
Christen, A. G. (1991) · JAMA · doi:10.1001/jama.1991.03470220049025 · Cited by 318
Nicotine-mecamylamine treatment for smoking cessation: The role of pre-cessation therapy.
Rose, J. E., Behm, F. M., & Westman, E. C. (1998) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.6.3.331 · Cited by 159
Efficacy of Bupropion and Nortriptyline for Smoking Cessation Among People at Risk for or With Chronic Obstructive Pulmonary Disease
Wagena, E. J., Knipschild, P. G., Huibers, M. J. H., Wouters, E. F. �., & van Schayck, O. C. P. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.19.2286 · Cited by 141

Flagged first, then by citations

Show all 14 references

Sorted by citations

Items 301–379 of 379

Eficacia y seguridad de vareniclina en el abandono del tabaquismo
Reina, S. S., Lozano, P. V., García-Tenorio, R. S., Nieto, J. C. M., Orive, J. I. D. G., & Ruiz, C. A. J. (2012) · Revista de Fomento Social · doi:10.1016/s1576-9895(12)70132-7 · Cited by 2
Effects of short-term varenicline administration on cortisol in healthy, non-smoking adults: a randomized, double-blind, study
Mocking, R. J. T., Wever, S. A., Pflanz, C. P., Pringle, A., Parsons, E., McTavish, S. F. B., Cowen, P. J., Harmer, C. J., & Schene, A. H. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3213-7 · Cited by 2
Physician and Pharmacist Care of Varenicline Users in a Real-World Setting
Frandsen, M., & Ferguson, S. G. (2013) · The Journal of Smoking Cessation · doi:10.1017/jsc.2013.2 · Cited by 2
Spécificité du sevrage tabagique chez l’asthmatique et effets du sevrage sur l’asthme
Underner, M., Peiffer, G., Perriot, J., & Jaafari, N. (2021) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2020.11.003 · Cited by 2
Changes in distinct brain systems identified with fMRI during smoking cessation treatment with varenicline: a review
Panagopoulos, V. N., Bailey, A., Kostopoulos, G., & Ioannides, A. A. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06556-2 · Cited by 3
The potential of AB-free kava in enabling tobacco cessation via management of abstinence-related stress and insomnia: study protocol for a randomized clinical trial
Xing, C., Malaty, J. Z., Malham, M. B., Orlando, F. A., Lynch, A. M., Huo, Z., François, M., Firpi-Morell, R. J., Fisher, C. L., Christou, D. D., et al. (2024) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-024-04722-9 · Cited by 2
Varenicline and evaluated outcomes in smoking cessation programmes
Santus, P., Bassi, L., Airoldi, A., Giovannelli, F., & Radovanovic, D. (2015) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2013.105 · Cited by 2
Pharmacotherapy of Alcohol and Drug Dependence
Swift, R. M., & Aoun, E. G. (2014) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-014-0029-7 · Cited by 2
Diagnosis of abuse and addiction
Lesch, O., Walter, H., Wetschka, C., Hesselbrock, M. N., & HESSELBROCK, V. M. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0146-9_5 · Cited by 2
Cost-effectiveness of Smoking Cessation in Japan
YASUDA, H., & Ikeda, S. (2009) · Japanese Journal of Pharmacoepidemiology/Yakuzai ekigaku · doi:10.3820/jjpe.14.61 · Cited by 2
Reducing tobacco-associated lung cancer risk: a study protocol for a randomized clinical trial of AB-free kava
Xing, C., Malaty, J. Z., Malham, M. B., Nehme, A. M. A., Freeman, B., Huo, Z., Firpi-Morrel, R., & Salloum, R. G. (2023) · Trials · doi:10.1186/s13063-023-07081-x · Cited by 2
Die medikamentöse Therapie von Missbrauch und Abhängigkeiten (Tabak, Alkohol und illegale Drogen)
Lesch, O., Platz, W. E., Soyka, M., & Walter, H. (2010) · Springer eBooks · doi:10.1007/978-3-211-85473-0_18 · Cited by 2
Tratamiento farmacológico del tabaquismo
Sergio Bello, S., Alvaro Flores, C., & S, M. B. (2008) · Revista chilena de enfermedades respiratorias · doi:10.4067/s0717-73482008000200007 · Cited by 2
Paecilomycies japonica reduces repeated nicotine-induced neuronal and behavioral activation in rats
Ye, M., Lee, H.-J., Bae, H., Hahm, D., Lee, H., & Shim, I. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0739-8 · Cited by 1
Use of low-dose varenicline in hospitalized smokers: A case series low-dose varenicline in hospitalized smokers
Joyner, R. L., Phillips, R. E., Manshaii, F., & Davis, J. M. (2025) · SAGE Open Medical Case Reports · doi:10.1177/2050313x251338637 · Cited by 1
Nicotinic Receptors and Mental Illness
Leonard, S. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1167-7_20 · Cited by 1
Smoking: A Deadly Pleasant Habit—Is There a Way Out?
Richter, D. J. (2008) · Angiology · doi:10.1177/0003319708321747 · Cited by 1
Varenicline and Risk of Self-Harm: A Nested Case-Control Study
Tadrous, M., Martins, D., Yao, Z., Mamdani, M., Juurlink, D. N., Gomes, T., & Antoniou, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163681 · Cited by 1
A Systematic Review Investigating the Impact of Modified Varenicline Regimens on Smoking Cessation
Drovandi, A. D., Teague, P.-A., Glass, B. D., & Malau‐Aduli, B. S. (2017) · The Journal of Smoking Cessation · doi:10.1017/jsc.2017.3 · Cited by 1
Life-Threatening Angioedema Following Varenicline Administration
Seak, C., Goh, Z. N. L., Seak, J. C.-Y., Seak, C.-K., & Li, C.-H. (2019) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001036 · Cited by 1
Use of low-dose varenicline in patients who do not tolerate standard-dose varenicline: A longitudinal case series
Swanson, M., Masclans, L., & Davis, J. M. (2025) · Tobacco Prevention & Cessation · doi:10.18332/tpc/194629 · Cited by 1
Integrative Therapies for Tobacco Cessation
Hathaway, K. M., & Erasmus, Y. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-579-4_13 · Cited by 1
Approaches to Smoking Cessation in a Cardiovascular Population
Sohn, M., Shishani, K., Okada, A., & Froelicher, E. S. (2012) · Springer eBooks · doi:10.1007/978-1-4419-5650-7_15 · Cited by 1
Smoking cessation aids
Roopchandani, K., Singhvi, I., & Kar, M. (2008) · Asian Journal of Pharmaceutics · doi:10.22377/ajp.v2i4.205 · Cited by 1
Factors Associated With Tobacco Use Among Patients With MCC: Multidisciplinary Visions about the Lifestyle on Health and Cardiovascular Disease
Galil, A. G. D. S., Gomes, A. D. S., de Andrade, B. A. B. B., Gusmão, M. M., Campos, T. D. S., de Melo, M. M., & Banhato, E. F. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811279-3.00019-7 · Cited by 1
Therapeutic Strategies in Alcohol and Tobacco Addiction
Lesch, O., Walter, H., Wetschka, C., Hesselbrock, M. N., HESSELBROCK, V. M., & Pombo›, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-41941-7_9 · Cited by 1
Smoking cessation: primacy in cardiovascular disease prevention
Pipe, A. (2008) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32830bfa75 · Cited by 1
Pharmacology of drugs used to treat smoking cessation and obesity
Johns, K., Frohlich, J., & Bondy, G. P. (2008) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(08)71034-1 · Cited by 1
A Mobile Device Based Intervention to Reduce the Influence of Smoking Cues Among African American Cigarette Smokers
Robinson, C. D. (2015) · Defense Technical Information Center (DTIC) · doi:10.21236/ad1012741 · Cited by 1
Effects of Varenicline on Cue-reactivity in Individuals with Concurrent Tobacco Dependence and Heavy Alcohol Use: A Randomized, Double-blind, Placebo-controlled Trial
Wang, S. (2010) · Library and Archives Canada (Government of Canada) · Cited by 1
茶质滤嘴的祛烟瘾减害作用研究
张, 惠., 张, 俊., 陶, 然., 常, 彦., 黄, 秀., 张, 龙., 赵, 燕., 刘, 彩., 梁, 永., 赵, 保., et al. (2010) · Scientia Sinica Vitae · doi:10.1360/zc2010-40-5-375
DRUG ADDICTION
Choi, D., Karpyak, V. M., Frye, M. A., Hall‐Flavin, D. K., & Mrazek, D. A. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3291-5.50059-7 · Cited by 1
Psychophysiological and fMRI investigations of tobacco cue reactivity.
Engelmann, J. M. (2010) · University of Minnesota Digital Conservancy (University of Minnesota)
EFFECT OF SMOKING AND CESSATION IN HIV-INFECTED PEOPLE
Cui, Q. (2011) · MacSphere (McMaster University) · doi:10.71548/18671
Pulsicooximetría, cooximetría en aire espirado y análisis de cotinina en orina en la valoración del consumo de tabaco y factores de riesgo cardiovascular en fumadores en deshabituación
Marqués, J. S.-B. (2012) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/1421
Pharmacotherapy for smoking.
Allan, G. M., Ivers, N. M., & Els, C. (2011) · PubMed Central
Terapia farmacológica para el abandono del tabaquismo
Becerra, N., Cañón, M., & Vivas, J. M. (2010) · Universitas Médica · doi:10.11144/javeriana.umed51-2.tfpa
Effectiveness of Varenicline in Psychiatric Patients with Co-Morbid Polysubstance Dependence
Kim, J., Kaul, P., Schwartz, T. L., & Megna, J. L. (2014) · The Journal of Smoking Cessation · doi:10.1017/jsc.2014.10
Werkzaamheid en veiligheid van varenicline, met als indicatie het stoppen met roken
Bruijnzeel, P. L. B. (2007) · Medisch-Farmaceutische Mededelingen · doi:10.1007/bf03058920
Recent developments for smoking cessation and treatment of nicotine dependence
Balbani, A. P. S., & Montovani, J. C. (2007) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.17.3.287
Sensitivity Analysis of the Efficacy of Varenicline in Smoking Cessation With a Special Reference to Study Dropouts
Oshima, A., Ito, Y., & Nomura, H. (2009) · The Journal of Smoking Cessation · doi:10.1375/jsc.4.2.86
Smoking cessation in patients with chronic obstructive pulmonary disease and lung cancer
Jimenez-Ruiz, C. A. (2008) · Hot Topics in Respiratory Medicine · doi:10.4147/htr-080815
Smoking cessation: the ongoing challenge
O’Connell, N. (2008) · Nurse Prescribing · doi:10.12968/npre.2008.6.4.29103
Uso de varenicline no tratamento do tabagismo: relato de dois casos
Horimoto, F. C., & Bevilaqua, M. (2007) · Revista de Psiquiatria do Rio Grande do Sul · doi:10.1590/s0101-81082007000200014
Pharmacological Therapy in Smoking Cessation
Mahmood, M., Hoque, H., Rahman, M. M., Zaman, S. M., Salim, M. A., Arzu, J., & Adhikary, D. K. (2014) · University Heart Journal · doi:10.3329/uhj.v9i1.19509
Varenicline: a new pharmacotherapy for smoking cessation in primary care practice
Robson, N. (2011) · South African Family Practice · doi:10.1080/20786204.2011.10874088
Therapeutic Options in Smoking Cessation
Galant, L. M. (2010) · Clinical Medicine Reviews in Therapeutics · doi:10.4137/cmrt.s5099
Varenicline - a new pharmacotherapy for smoking cessation in primary care practice
Othman, S. A. I., & Yusoff, H. B. M. (2010)
Another Arrow in the Quiver to Combat Smoking
Masoudi, F. A., & Msph (2006) · Journal watch · doi:10.1056/jc200609130000004
Tabaquismoytrastornomentalgrave:conceptualiza- ción,abordajeteóricoyestudiosdeintervención.
de Psiquiatría, S., & Machado, A. (2012)
The Effects of Varenicline on Neurocognitive Function in Non-smokers with Schizophrenia
Kozak, K. (2016) · TSpace (University of Toronto)
Thuốc và các hướng điều trị mới trong bệnh phổi tắc nghẽn mãn tính (COPD)
Carine, B. D.-N. (2011)
Effect of Varenicline vs. Placebo on Reactivity to Tobacco and Alcohol Cues in Smokers who are Light Drinkers
Staios, G. (2011) · TSpace (University of Toronto)
Network meta-analysis: a comparison of effectiveness and safety of partial agonists of nicotinic acetylcholine receptors varenicline and cytisine for smoking cessation
Radchenko, E. V., Sykhovskaya, O. A., Леонидович, Г. Т., Колбин, А. С., & Smirnova, M. A. (2018) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf16419-32
Farmakoterapia wspomagająca w leczeniu uzależnienia od alkoholu i narkotyków
Swift, R. M., & Leggio, L. (2013) · Wydawnictwa Uniwersytetu Warszawskiego eBooks · doi:10.31338/uw.9788323513759.pp.287-312
Development of a Translational Model of Co-Use of Alcohol and Nicotine for Testing Potential Pharmacotherapies
Maggio, S. E. (2019) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2019.395
Agents for Treatment of Withdrawal and Dependency: Varenicline
Jacob, C. C., & Polak, T. T. (2020) · Springer eBooks · doi:10.1007/978-3-319-56015-1_350-1
Diagnose von Missbrauch und Abhängigkeit
Lesch, O., Walter, H., Hesselbrock, M. N., & HESSELBROCK, V. M. (2020) · Springer eBooks · doi:10.1007/978-3-662-60284-3_5
Therapeutische Strategien bei Alkohol- und Tabakabhängigkeit
Lesch, O., Walter, H., Pombo›, S., HESSELBROCK, V. M., & Hesselbrock, M. N. (2020) · Springer eBooks · doi:10.1007/978-3-662-60284-3_9
Optimizing medical therapy in the coronary artery bypass graft patient
Lazar, H. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820348-4.00024-8
Varenicline: un nuevo tratamiento farmacológico para dejar de fumar
Bakalar, K., & Schoj, V. (2007) · Evidencia actualizacion en la práctica ambulatoria · doi:10.51987/evidencia.v10i2.5661
Evidence of individual differences in motives for nicotine seeking in classical nicotine self-administration and associated outcomes of varenicline administrationPreprint
Garcia‐Rivas, V., Fiancette, J.-F., Tostain, J., de Maio, G., Wiart, J., Gaulier, J., & Deroche‐Gamonet, V. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.05.463198
Current awareness: Pharmacoepidemiology and drug safety
(2007) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1369
References
(2011) · Wiley eBooks · doi:10.1002/9781118101056.refs
Les interventions en psychologie de la santé
Mikolajczak, M. (2013) · Dunod eBooks · doi:10.3917/dunod.mikol.2013.01.0257
Suchtkrankheiten
Broocks, A., & Thürauf, N. (2013) · Elsevier eBooks · doi:10.1016/b978-3-437-31610-4.00027-8
The Pharmacist's Role in Smoking Cessation
Wick, J. Y. (2008) · The Consultant Pharmacist · doi:10.4140/tcp.n.2008.68
Diagnosis of Abuse and Addiction
Lesch, O., Walter, H., Wetschka, C., Hesselbrock, M. N., HESSELBROCK, V. M., & Pombo›, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-41941-7_5
Μεταβολές της ποιότητας ζωής κατόπιν παρέμβασης διακοπής καπνίσματος σε νοσηλευόμενους ασθενείς με αναπνευστικά προβλήματα
Πολίτης, Α. (2018) · doi:10.12681/eadd/44324
Suchtkrankheiten
Broocks, A., & Thürauf, N. (2015) · Elsevier eBooks · doi:10.1016/b978-3-437-24265-6.00021-4
Acneiform Eruption Caused By Varenicline Tartrate: A Case Report
(2015) · Journal of the Turkish Academy of Dermatology · doi:10.6003/jtad.1593c2
Agents for Treatment of Withdrawal and Dependency: Varenicline
Jacob, C. C., & Polak, T. T. (2022) · Springer eBooks · doi:10.1007/978-3-030-62059-2_350
Insomnia and parasomnia induced by validated smoking cessation pharmacotherapies and electronic cigarettes: a network meta-analysis
Vanderkam, P., Pomes, C., Dzeraviashka, P., Castéra, P., Jaafari, N., & Lafay‐Chebassier, C. (2024) · CNS Spectrums · doi:10.1017/s1092852924000087
A Smoking Cessation Program Using Vouchers with Individuals with Traumatic Brain Injury
Erickson, T. K. (2012) · Digital Commons - University of South Florida (University of South Florida)
Additional file 1 of Reducing tobacco-associated lung cancer risk: a study protocol for a randomized clinical trial of AB-free kava
Xing, C., Malaty, J. Z., Malham, M. B., Nehme, A. M. A., Freeman, B., Huo, Z., Firpi-Morrel, R., & Salloum, R. G. (2023) · Figshare · doi:10.6084/m9.figshare.22610116
Additional file 2 of Reducing tobacco-associated lung cancer risk: a study protocol for a randomized clinical trial of AB-free kava
Xing, C., Malaty, J. Z., Malham, M. B., Nehme, A. M. A., Freeman, B., Huo, Z., Firpi-Morrel, R., & Salloum, R. G. (2023) · Figshare · doi:10.6084/m9.figshare.22610119
Toxicity induced by ion channel targeting drugs: Mechanisms and mitigation strategies
Krüger, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29808-0.00070-4
Approche thérapeutique et cognitive chez les patients souffrant d'une addiction au tabac
Vanderkam, P. (2023) · theses.fr (ABES) · doi:10.70675/307f9e53z9985z46a6z8c9dz1701c02f2849
One-Year Outcomes of Bioresonance Therapy for Smoking Cessation: A Prospective Primary Care Study
Dur, G., & Şensoy, N. (2026) · International Journal of Traditional and Complementary Medicine Research · doi:10.53811/ijtcmr.1929955

Authors: Oncken, C.
Affiliations: UConn Health (US)
Corresponding author: Oncken, Cheryl
ORCID: Oncken, Cheryl
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 2006-08-14
Volume: 166
Issue: 15
Pages: 1571
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.166.15.1571
OpenAlex: W2113308458
Cited by: 380
References: 14
Citations by year: 2026: 2 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 4 · 2021: 9 · 2020: 13 · 2019: 7 · 2018: 13 · 2017: 9 · 2016: 15 · 2015: 28 · 2014: 23 · 2013: 17 · 2012: 28
FWCI: 26.09
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: varenicline, smoking cessation, dose titration, abstinence rates, nausea, drug safety, nicotine dependence
MeSH terms: Varenicline, Adolescent, Adult, Aged, Benzazepines, Double-Blind Method, Female, Humans, Male, Middle Aged, Quinoxalines, Tobacco Use Disorder, Smoking Cessation, Treatment Outcome, Nicotinic Agonists, Nicotinic Antagonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Efficacy and Safety of the Novel Selective Nicotinic Acetylcholine Receptor Partial Agonist, Varenicline, for Smoking Cessation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks