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The Pathophysiology and Clinical Characteristics of Severe Hypophosphatemia
Abstract
Hypophosphatemia, with or without phosphorus deficiency, is found commonly in patients with a variety of disease states. Severe hypophosphatemia is most often observed in chronic alcoholics, patients recovering from diabetic ketoacidosis, and those being therapeutically refed after severe weight loss. Its consequences may be severe and contribute to mortality. The following represents a selective review of available literature on this subject published over the past 50 years and a limited number of observations on patients and experimental animals. An attempt is made to examine mechanisms by which hypophosphatemia and phosphorus depletion probably occur, outline the resulting clinical disturbances, and suggest a plan of treatment. Finally, this review will hopefully point out areas of this interesting deficiency state that desperately need further investigation.
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Citations
Cited by
Refeeding syndrome: what it is, and how to prevent and treat it
Mehanna, H. M., Moledina, J., & Travis, J. (2008) · BMJ · doi:10.1136/bmj.a301 · Cited by 706
ASPEN Consensus Recommendations for Refeeding Syndrome
da Silva, J. S. V., Seres, D. S., Sabino, K., Adams, S. C., Berdahl, G. J., Citty, S. W., Cober, M. P., Evans, D. C., Greaves, J. R., Gura, K. M., et al. (2020) · Nutrition in Clinical Practice · doi:10.1002/ncp.10474 · Cited by 542
Clinical and Metabolic Features of Thyrotoxic Periodic Paralysis in 24 Episodes
Manoukian, M. A., Foote, J. A., & Crapo, L. M. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.6.601 · Cited by 255
Alcohol withdrawal syndromes: A review of pathophysiology, clinical presentation, and treatment
Turner, R. C., Lichstein, P. R., Peden, J. G., Busher, J. T., & Waivers, L. E. (1989) · Journal of General Internal Medicine · doi:10.1007/bf02599697 · Cited by 108
Hypophosphataemia in old patients is associated with the refeeding syndrome and reduced survival
KAGANSKY, N., LEVY, S., KOREN‐MORAG, N., BERGER, D., & KNOBLER, H. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01457.x · Cited by 94
Metadata
- Authors
- Knochel, J. P.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1977-02-01
- Volume
- 137
- Issue
- 2
- Pages
- 203
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2076079580
- Cited by
- 568
- References
- 0
- FWCI
- 23.43
- Type
- journal article
- Language
- en
- Open access
- closed
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