Neuropsychiatric Manifestations of Patients With Cushing's Syndrome: Relationship to Cortisol and Adrenocorticotropic Hormone Levels
Abstract
• Thirty-five consecutive patients with Cushing's syndrome were studied prospectively before treatment. A consistent constellation of neuropsychiatric disturbances was found, including impairments in affect (depressed mood and crying), cognitive functions (decreased concentration and memory), and vegetative functions (decreased libido and insomnia). Thirty-four percent of patients were rated as having a mild, 26% a moderate, 29% a severe, and 11% a very severe psychiatric disability. A statistically significant relationship was found between the overall neuropsychiatric disability rating and cortisol and adrenocorticotropic hormone (ACTH) levels. Patients with adrenal adenomas with high cortisol but low ACTH levels did not have as severe a neuropsychiatric disability. (Arch Intern Med141:215-219, 1981)
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In Cushing's disease, depressive symptoms can be relieved by surgical correction of the hypercortisolemia.
“In Cushing's disease, there are depressive symptoms that can be relieved by surgical correction of the hypercortisolemia.110,111”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [111]
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Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 4,981 · see citing works
Protective and damaging effects of stress mediators: central role of the brain
McEwen, B. S. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/bmcewen · Cited by 1,220 · see citing works
- Authors
- Starkman, M. N.
- Corresponding author
- Starkman, Monica N.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1981-02-01
- Volume
- 141
- Issue
- 2
- Pages
- 215
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W7214217099
- Cited by
- 5
- References
- 0
- Citations by year
- 2026: 1 · 2023: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- Cushing's syndrome, neuropsychiatric symptoms, psychiatric disability, depression, cognitive impairment, memory, insomnia, low libido, cortisol, ACTH, adrenal adenoma, hypercortisolism
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