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The Effect of Prescribed Daily Dose Frequency on Patient Medication Compliance
Abstract
The objective of this study was to determine the relationship between prescribed daily dose frequency and patient medication compliance. The medication compliance of 105 patients receiving antihypertensive medications was monitored by analyzing data obtained from special pill containers that electronically record the date and time of medication removal. Inaccurate compliance estimates derived using the simple pill count method were thereby avoided. Compliance was defined as the percent of days during which the prescribed number of doses were removed. Compliance improved from 59.0% on a three-time daily regimen to 83.6% on a once-daily regimen. Thus, compliance improves dramatically as prescribed dose frequency decreases. Probably the single most important action that health care providers can take to improve compliance is to select medications that permit the lowest daily prescribed dose frequency.
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Citations
Cited by
Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974
A systematic review of the associations between dose regimens and medication compliance
Claxton, A. J., Cramer, J., & Pierce, C. (2001) · Clinical Therapeutics · doi:10.1016/s0149-2918(01)80109-0 · Cited by 2,388
Medication compliance and persistence: terminology and definitions
Cramer, J. A., Roy, A., Burrell, A., Fairchild, C. J., Fuldeore, M. J., Ollendorf, D. A., & Wong, P. K. (2008) · Value in Health · doi:10.1111/j.1524-4733.2007.00213.x · Cited by 2,220
Social support and patient adherence to medical treatment: a meta-analysis.
DiMatteo, M. R. (2004) · Health Psychology · doi:10.1037/0278-6133.23.2.207 · Cited by 2,107
Lustman, P. J., Griffith, L. S., Freedland, K. E., Kissel, S. S., & Clouse, R. E. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-129-8-199810150-00005 · Cited by 562
Metadata
- Authors
- Eisen, S. A.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association
- Published
- 1990-09-01
- Volume
- 150
- Issue
- 9
- Pages
- 1881-1881
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2069947800
- Cited by
- 817
- References
- 0
- FWCI
- 28.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eisen, S. A. (1990). The Effect of Prescribed Daily Dose Frequency on Patient Medication Compliance. Archives of Internal Medicine. https://doi.org/10.1001/archinte.150.9.1881
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
