Leukopenia, Neutropenia, and Reduced Hemoglobin Levels in Healthy American Blacks
Abstract
Hematologic profiles of 462 persons, mostly active-duty service members, were studied to determine whether hematologic differences between blacks and whites exist in a healthy population. Whites had significantly greater mean concentrations of leukocytes (6.73 vs 5.95 x 10(9)/L), neutrophils (3.96 vs 3.16 x 10(9)/L), and hemoglobin (153 vs 135 g/L for men, 147 vs 125 g/L for women). The mean differences were largely due to relatively symmetric shifts in the frequency distributions for these cell concentrations. No significant correlation was found between neutrophil count and morbidity from infection as measured by a standardized questionnaire. The use of separate hematologic reference values for blacks and whites should be considered.
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Low white blood cell counts are common in patients with Graves' disease and in African Americans, 10% of whom have a neutrophil count under 2000, and abnormal liver enzymes are frequently seen in patients with thyrotoxicosis.
“This suggestion is made in part because low WBC counts are common in patients with GD and in African Americans [10% of whom have a neutrophil count under 2000 (148)], and abnormal liver enzymes are frequently seen in patients with thyrotoxicosis (149).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [148]
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References 25 · Cited by 129
- Authors
- Reed, W. W.
- Affiliations
- Walter Reed National Military Medical Center (US)
- Corresponding author
- Reed, William W.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1991-03-01
- Volume
- 151
- Issue
- 3
- Pages
- 501
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2099497955
- Cited by
- 129
- References
- 25
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 1 · 2013: 5 · 2012: 2
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Race, Genetics, and Society
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- leukopenia, neutropenia, anemia, hemoglobin, racial differences, African Americans, hematological reference values, white blood cell count, neutrophil count, infection morbidity, military personnel
- MeSH terms
- Adult, Black or African American, Female, Hemoglobins, Humans, Leukocyte Count, Leukopenia, Male, Morbidity, Neutropenia, Platelet Count, Reference Values, Regression Analysis, United States, Black People, White People
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