The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Symptoms Associated With Tamoxifen Treatment in Postmenopausal Women
Abstract
Adjuvant breast cancer therapy with tamoxifen is associated with greater disease-free survival and possibly overall survival. Long-term treatment, possibly of indefinite duration, is being evaluated. Compliance with long-term therapy will depend largely on the nature and severity of tamoxifen's side effects. We evaluated the symptoms associated with tamoxifen therapy in 140 postmenopausal women with axillary node negative breast cancer in remission (mean years since menopause, 9.3) enrolled in a placebo-controlled, randomized toxicity study. Tamoxifen recipients reported moderated or severe vasomotor symptoms up to 17%, and gynecologic symptoms up to 4% more frequently than placebo subjects. Persistent vasomotor, gynecologic, or other major side effects were reported by 48% of tamoxifen recipients, and by 21% of placebo subjects. These carefully collected data suggest significant perceived symptom 'cost' of tamoxifen therapy in postmenopausal women, of a magnitude likely to compromise long-term compliance.
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Cites
Side effects and emotional distress during cancer chemotherapy
Love, R. R., Leventhal, H., Easterling, D. V., & Nerenz, D. R. (1989) · Cancer · doi:10.1002/1097-0142(19890201)63:3<604::aid-cncr2820630334>3.0.co;2-2 · Cited by 338
Self-citationLove, R. R., Newcomb, P. A., Wiebe, D. A., Surawicz, T. S., Jordan, V. C., Carbone, P. P., & DeMets, D. L. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.16.1327 · Cited by 292
Self-citationOsborne, C. K., Boldt, D. H., Clark, G. M., & Trent, J. M. (1983) · PubMed · Cited by 278
Sutherland, R. L., Green, M. D., Hall, R. E., Reddel, R. R., & Taylor, I. W. (1983) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(83)90177-3 · Cited by 209
Fisher, B., BROWN, A., Wolmark, N., REDMOND, C., Wickerham, D. L., WITTLIFF, J., DIMITROV, N., LEGAULT-POISSON, S., SCHIPPER, H., & PRAGER, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-5-649 · Cited by 120
Prospects for Antiestrogen Chemoprevention of Breast Cancer
Love, R. R. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.1.18 · Cited by 54
Self-citation
Cited by
El Khoudary, S. R., Aggarwal, B., Beckie, T. M., Hodis, H. N., Johnson, A. E., Langer, R. D., Limacher, M. C., Manson, J. E., Stefanick, M. L., Allison, M. A., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000912 · Cited by 1,219
Ganz, P. A., Rowland, J. H., Desmond, K., Meyerowitz, B. E., & Wyatt, G. E. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.2.501 · Cited by 963
Insomnia in the Context of Cancer: A Review of a Neglected Problem
Savard, J., & Morin, C. M. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.3.895 · Cited by 861
Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer
Partridge, A. H., Wang, P. S., Winer, E. P., & Avorn, J. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.07.071 · Cited by 676
Major depression after breast cancer: a review of epidemiology and treatment
Fann, J. R., Thomas-Rich, A. M., Katon, W. J., Cowley, D., Pepping, M., McGregor, B. A., & Gralow, J. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.10.008 · Cited by 586
Metadata
- Authors
- Love, R. R.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1991-09-01
- Volume
- 151
- Issue
- 9
- Pages
- 1842
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W1989446922
- Cited by
- 273
- References
- 6
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
