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Cited by 402Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Alzheimer's Neurofibrillary Changes: A Topographic Study

HIRANO, ASAO·1962·Archives of Neurology
DOI 10.1001/archneur.1962.04210030065009
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Abstract

Introduction The significance of Alzheimer's neurofibrillary changes has been actively discussed by neuropathologists over the past half a century, and numerous reports have been written concerning it. Their clinicoanatomical correlation with mental disease, their relation to senile plaques and other changes associated with aging, their cytological demonstration with silver impregnation techniques, as well as experimental attempts at their reproduction, have engaged many investigators. Topographic aspects of this neuronal alteration have been analyzed in certain parts of the central nervous system in a few conditions—the cerebral cortex in Alzheimer's disease and the senile psychoses, and the substantia nigra and brain stem in parkinsonism. Recent observations of neurofibrillary changes in 2 fatal neurologic diseases occurring on the island of Guam, the parkinsonism-dementia complex (Hirano, Kurland, Krooth, and Lessell1; Hirano, Malamud and Kurland2) and the amyotrophic lateral sclerosis syndrome (Malamud, Hirano and Kurland3), revealed their quite remarkable numbers and symmetric

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Crossref · 10.1001/archneur.1962.04210030065009

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Metadata

Authors
HIRANO, A.
Corresponding author
HIRANO, ASAO
Venue
Archives of Neurology
Publisher
American Medical Association (AMA)
Published
1962-09-01
Volume
7
Issue
3
Pages
227
ISSN
0003-9942 (ISSN-L)
DOI
10.1001/archneur.1962.04210030065009
OpenAlex
W2028666162
Cited by
402
References
31
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, neurofibrillary tangles, amyloid plaques, parkinsonism-dementia complex, amyotrophic lateral sclerosis, Guam, silver impregnation, neuropathology, cerebral cortex, substantia nigra, brainstem, aging
MeSH terms
Amyotrophic Lateral Sclerosis, Brain, Brain Diseases, Dementia, Hepatolenticular Degeneration, Humans, Parkinson Disease, Psychotic Disorders, Neurofibrillary Tangles

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