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Progressive Supranuclear Palsy: A Heterogeneous Degeneration Involving the Brain Stem, Basal Ganglia and Cerebellum With Vertical Gaze and Pseudobulbar Palsy, Nuchal Dystonia and Dementia

STEELE, JOHN C.·1964·Archives of Neurology

Abstract

Introduction In this report we are describing a progressive brain disease featured by supranuclear ophthalmoplegia affecting chiefly vertical gaze, pseudobulbar palsy, dysarthria, dystonic rigidity of the neck and upper trunk, and other less constant cerebellar and pyramidal symptoms. Dementia has usually remained mild. This disease would appear to be predominantly a nerve cell degeneration centered chiefly in the brain stem. The fully developed clinical picture presented by this disease seems to follow a fairly definitive pattern and does not conform to the classical system degenerations such as motor neurone disease, paralysis agitans, cerebellar degeneration, Creuzfeldt-Jakob disease, or the presenile dementias. Yet it would seem unlikely that the disease shown by our cases is a new one, and similar earlier cases may well have been accepted as arteriosclerotic parkinsonism when that diagnosis was used in a very broad sense such as in Critchley's monograph of 1929. 1 There are some resemblances to

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Metadata

Authors
STEELE, J. C.
Venue
Archives of Neurology
Published
1964-04-01
Volume
10
Issue
4
Pages
333
ISSN
0003-9942 (ISSN-L)
OpenAlex
W2019254928
Cited by
1,924
References
8
FWCI
3.14
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Progressive Supranuclear Palsy: A Heterogeneous Degeneration Involving the Brain Stem, Basal Ganglia and Cerebellum With Vertical Gaze and Pseudobulbar Palsy, Nuchal Dystonia and Dementia. https://app.cochat.ai/papers/10.1001/archneur.1964.00460160003001
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STEELE, J. C. (1964). Progressive Supranuclear Palsy: A Heterogeneous Degeneration Involving the Brain Stem, Basal Ganglia and Cerebellum With Vertical Gaze and Pseudobulbar Palsy, Nuchal Dystonia and Dementia. Archives of Neurology. https://doi.org/10.1001/archneur.1964.00460160003001

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