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Carbamazepine in the Treatment of Neuralgia: Use and Side Effects
Abstract
CARBAMAZEPINE (Tegretol) has been used for more than eight years in other countries for the treatment of epilepsy and, more recently, trigeminal neuralgia. The earliest reports on its effect in trigeminal neuralgia were by Blom1,2in Sweden, Bonduelle et al3in France, and Spillane4and Taylor5in England. Since then, there have been a number of additional papers.6-9The authors are in agreement on the effectiveness of this drug in trigeminal neuralgia, but the type and number of side effects have been quite variable. There have been occasional reports of serious hematopoietic effects,10,11but no repeated blood studies over long periods have been reported. The present study was undertaken to evaluate the side effects and also the application of this drug in some of the other neuralgias such as postherpetic, tabetic, and atypical facial neuralgia. A double-blind technique was necessary. Carbamazepine is an
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Cited by
AAN-EFNS guidelines on trigeminal neuralgia management
Cruccu, G., Gronseth, G., Alksne, J., Argoff, C., Brainin, M., Burchiel, K., Nurmikko, T., & Zakrzewska, J. M. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02185.x · Cited by 726
European Academy of Neurology guideline on trigeminal neuralgia
Bendtsen, L., Zakrzewska, J. M., Abbott, J., Braschinsky, M., Di Stefano, G., Donnet, A., Eide, P. K., Leal, P. R. L., Maarbjerg, S., May, A., et al. (2019) · European Journal of Neurology · doi:10.1111/ene.13950 · Cited by 668
Postherpetic Neuralgia — Pathogenesis, Treatment, and Prevention
Kost, R. G., & Straus, S. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607043350107 · Cited by 641
Trigeminal neuralgia—pathophysiology, diagnosis and current treatment
Nurmikko, T. J., & Eldridge, P. R. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.1.117 · Cited by 417
The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain
Hunter, J. C., Gogas, K. R., Hedley, L. R., Jacobson, L. O., Kassotakis, L., Thompson, J., & Fontana, D. J. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)00070-8 · Cited by 310
Metadata
- Authors
- Killian, J. M.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1968-08-01
- Volume
- 19
- Issue
- 2
- Pages
- 129
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2062270592
- Cited by
- 329
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Killian, J. M. (1968). Carbamazepine in the Treatment of Neuralgia: Use and Side Effects. Archives of Neurology. https://doi.org/10.1001/archneur.1968.00480020015001
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
