The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cerebral Blood Flow During
Abstract
IT IS WELL established that the arterial carbon dioxide tension (Pco2) is an important factor controlling cerebral vascular resistance (CVR) and cerebral blood flow (CBF) in healthy animals and man. An acute rise in Pco2causes a decrease in CVR which increases the CBF, and a fall in Pco2has the opposite effect. However, during sustained alteration of Pco2, the CBF and absolute carbon dioxide tension often fail to correlate closely, and much recent evidence summarized by Lassen1suggests that alterations of the pH of the brain's extracellular space mediate the cerebral vascular response to carbon dioxide and that brain interstitial fluid pH is the major regulator of CBF. The pH hypothesis is physiologically attractive, but evidence against it comes from a series of experiments in several laboratories in which prolonged passive hyperventilation of animals2-5and man6producing sustained, constant arterial hypocapnia
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Citations
Cites
Kety, S. S., & Schmidt, C. F. (1948) · Journal of Clinical Investigation · doi:10.1172/jci101995 · Cited by 1,827
Cited by
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630
Self-citationRaichle, M. E. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.01.008 · Cited by 1,111
Self-citationThe Effects of Changes in Pa CO 2 Cerebral Blood Volume, Blood Flow, and Vascular Mean Transit Time
GRUBB, R. L., RAICHLE, M. E., EICHLING, J. O., & TER-POGOSSIAN, M. M. (1974) · Stroke · doi:10.1161/01.str.5.5.630 · Cited by 1,044
Self-citationRegulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
Claassen, J. A. H. R., Thijssen, D. H. J., Panerai, R. B., & Faraci, F. M. (2021) · Physiological Reviews · doi:10.1152/physrev.00022.2020 · Cited by 915
Obrist, W. D., Langfitt, T. W., Jaggi, J. L., Cruz, J., & Gennarelli, T. A. (1984) · Journal of Neurosurgery · doi:10.3171/jns.1984.61.2.0241 · Cited by 835
Metadata
- Authors
- Raichle, M. E., Posner, J. B., & Plum, F.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1970-11-01
- Volume
- 23
- Issue
- 5
- Pages
- 394-403
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2094006219
- Cited by
- 274
- References
- 1
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Raichle, M. E., Posner, J. B., & Plum, F. (1970). Cerebral Blood Flow During. Archives of Neurology. https://doi.org/10.1001/archneur.1970.00480290014002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
