The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Serum Hormones in Male Epileptic Patients Receiving Anticonvulsant Medication
Abstract
Circulating sex and thyroid hormones, as well as the pituitary function, were assessed in 63 male patients with epilepsy receiving either a single medication of carbamazepine, phenytoin, or valproate or a combination of carbamazepine plus phenytoin or carbamazepine plus valproate. All therapeutic regimens, including carbamazepine and/or phenytoin were associated with low levels of circulating thyroxine (T4), free thyroxine (FT4), and dehydroepiandrosterone sulfate, and with low values for the free androgen index, and phenytoin and carbamazepine plus phenytoin were associated with high serum concentrations of sex hormone-binding globulin. These hormone parameters were unaffected by valproate monotherapy. It seems probable that accelerated hormone metabolism is responsible for the hormonal changes found in patients treated with carbamazepine and/or phenytoin. However, every drug regimen studied also had depressant and/or stimulatory effects on the function of the hypothalamic-pituitary axis. The diverse endocrine effects of different antiepileptic drug regimens should be considered when starting antiepileptic drug therapy.
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Administration of some antiepileptic drugs (phenobarbital, phenytoin, carbamazepine) can induce hepatic microsomal enzymes, resulting in an increase of SHBG concentration that lowers T bioavailability.
“Administration of some antiepileptic drugs (e.g., phenobarbital, phenytoin and carbamazepine) can induce hepatic microsomal enzymes. This results in an increase of SHBG concentration that in turn influences free circulating androgen levels, lowering T bioavailability [107–109].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [107]
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Cites
The effect of diphenylhydantoin on thyroxine metabolism in man
Larsen, P. R., Atkinson, A. J., Wellman, H. N., & Goldsmith, R. E. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106339 · Cited by 119
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Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96
Treatment of hypopituitarism in patients receiving antiepileptic drugs
Paragliola, R. M., Prete, A., Kaplan, P. W., Corsello, S. M., & Salvatori, R. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70081-6 · Cited by 22
Metadata
- Authors
- Isojarvi, J. I. T., Pakarinen, A. J., Ylipalosaari, P. J., & Myllyla, V. V.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1990-06-01
- Volume
- 47
- Issue
- 6
- Pages
- 670-676
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2148667829
- Cited by
- 166
- References
- 1
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 5
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- epilepsy, antiepileptic drugs, sex hormones, thyroid hormones, thyroxine, dehydroepiandrosterone sulfate, free androgen index, sex hormone-binding globulin, hypothalamic-pituitary axis, carbamazepine, phenytoin, valproic acid, male patients
- MeSH terms
- Adolescent, Adult, Anticonvulsants, Epilepsy, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Male, Middle Aged, Gonadal Steroid Hormones, Thyroid Hormones
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