The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Diagnostic Criteria for Sporadic Creutzfeldt-Jakob Disease
Abstract
BACKGROUND: Making a clinical diagnosis of sporadic Creutzfeldt-Jakob disease relies on the evaluation of rapidly progressive dementia, ataxia, myoclonus, changes on the electroencephalogram, and other neurological signs. A definite diagnosis, however, is confined to cases that have been evaluated neuropathologically or by equivalent diagnostic techniques. This places a high priority on the establishment of reliable neuropathologic methods for the investigation and diagnosis of Creutzfeldt-Jakob disease. OBJECTIVE: To evaluate existing morphological and laboratory diagnostic techniques to reach a consensus on the definition of "definite Creutzfeldt-Jakob disease." METHODS: The existing morphological techniques, particularly immunohistochemistry, used in 4 laboratories--Germany, Great Britain, Japan, and the United States--are evaluated, and various laboratory diagnostic techniques are discussed. RESULTS: Immunohistochemistry with antibodies against the prion protein combined with special tissue pretreatment regimens gives reliable diagnostic results and, for its applicability to formalin-fixed and paraffin-embedded tissue, is superior to other techniques that may be more sensitive but require fresh, unfixed brain tissue. CONCLUSIONS: Our experience suggests the following regimen for the diagnosis of suspected Creutzfeldt-Jakob disease: light microscopy of various brain regions, which in typical cases may lead to definite diagnosis. Immunohistochemistry with antibodies against the prion protein is preferable in all suspected cases of Creutzfeldt-Jakob disease and is mandatory whenever a routine histological workup does not yield definite results. Additional special techniques can be applied if required.
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A new variant of Creutzfeldt-Jakob disease in the UK
Will, R. G., Ironside, J. W., Zeidler, M., Estibeiro, K., Cousens, S. N., Smith, P. G., Alperovitch, A., Poser, S., Pocchiari, M., & Hofman, A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91412-9 · Cited by 2,707
Self-citationA novel progressive spongiform encephalopathy in cattle
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Scrapie prions aggregate to form amyloid-like birefringent rods
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Creutzfeldt-Jakob Disease (Spongiform Encephalopathy): Transmission to the Chimpanzee
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Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins
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Self-citation
Cited by
14-3-3 proteins in the nervous system
Berg, D., Holzmann, C., & Riess, O. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1197 · Cited by 616
Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt–Jakob disease
Zerr, I., Pocchiari, M., Collins, S., Brandel, J. P., de Pedro Cuesta, J., Knight, R. S. G., Bernheimer, H., Cardone, F., Delasnerie-Lauprêtre, N., Cuadrado Corrales, N., et al. (2000) · Neurology · doi:10.1212/wnl.55.6.811 · Cited by 481
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Differential Diagnosis for Bilateral Abnormalities of the Basal Ganglia and Thalamus
Hegde, A. N., Mohan, S., Lath, N., & Lim, C. C. T. (2011) · RadioGraphics · doi:10.1148/rg.311105041 · Cited by 351
EEG in Creutzfeldt–Jakob disease
Wieser, H. G., Schindler, K., & Zumsteg, D. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2005.12.007 · Cited by 300
Metadata
- Authors
- Kretzschmar, H. A., Ironside, J. W., DeArmond, S. J., & Tateishi, J.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1996-09-01
- Volume
- 53
- Issue
- 9
- Pages
- 913-920
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2043028254
- Cited by
- 288
- References
- 36
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
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