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Effects of Bilateral Subthalamic Stimulation on Cognitive Function in Parkinson Disease

Alegret, Montse, Junqué, Carme, Valldeoriola, Francesc, Vendrell, Pere, Pilleri, Manuela, Rumià, Jordi, Tolosa, Eduardo·2001·Archives of Neurology

Abstract

BACKGROUND: Chronic bilateral subthalamic deep brain stimulation (STN-DBS) is known to improve motor function in patients with Parkinson disease (PD). However, the possible effects of STN-DBS on neuropsychological functions have been studied less. OBJECTIVE: To investigate the effects of STN-DBS on neuropsychological functions in PD. DESIGN: Before-after trial. PATIENTS AND METHODS: Fifteen consecutive patients were assessed before and 3 months after implantation of stimulators for STN-DBS (postsurgical assessment with the stimulators switched on). Both assessments were performed with patients in a drug-free condition. The neuropsychological battery consisted of tests measuring memory and visuospatial and frontal functions. RESULTS: The comparison between presurgical and postsurgical performance showed a moderate deterioration in verbal memory and prefrontal and visuospatial functions, and a moderate improvement in a prefrontal task and obsessive-compulsive traits. The motor state improved in all patients. CONCLUSION: Therapy with STN-DBS improves motor symptoms in PD without any clinically relevant neuropsychological deterioration.

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Metadata

Authors
Alegret, M., Junqué, C., Valldeoriola, F., Vendrell, P., Pilleri, M., Rumià, J., & Tolosa, E.
Venue
Archives of Neurology
Published
2001-08-01
Volume
58
Issue
8
Pages
1223
ISSN
0003-9942 (ISSN-L)
OpenAlex
W2075346124
Cited by
236
References
3
FWCI
8.18
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Effects of Bilateral Subthalamic Stimulation on Cognitive Function in Parkinson Disease. https://app.cochat.ai/papers/10.1001/archneur.58.8.1223
The paper
Alegret, M., Junqué, C., Valldeoriola, F., Vendrell, P., Pilleri, M., Rumià, J., & Tolosa, E. (2001). Effects of Bilateral Subthalamic Stimulation on Cognitive Function in Parkinson Disease. Archives of Neurology. https://doi.org/10.1001/archneur.58.8.1223

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