The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Lymphocyte Oxidative DNA Damage and Plasma Antioxidants in Alzheimer Disease
Abstract
CONTEXT: A large body of experimental evidence suggests that in Alzheimer disease (AD) pathogenesis an important role is played by oxidative stress, but there is still a lack of data on in vivo markers of free radical-induced damage. OBJECTIVES: To evaluate levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative damage to DNA, in peripheral lymphocytes; to measure plasma concentrations of several nonenzymatic antioxidants; and to assess the relationships between any observed changes in lymphocyte DNA 8-OHdG content and plasma antioxidant levels in patients with AD and healthy aged control subjects. SUBJECTS: Forty elderly outpatients with AD and 39 healthy age- and sex-matched controls were studied. MAIN OUTCOME MEASURES: The level of 8-OHdG was determined in DNA extracted from lymphocytes and plasma levels of vitamin C, vitamin A, vitamin E, and carotenoids (zeaxanthin, beta-cryptoxanthin, lycopene, lutein, and alpha- and beta-carotene) were measured by high-performance liquid chromatography. RESULTS: Lymphocyte DNA 8-OHdG content was significantly higher and plasma levels of antioxidants (with the exception of lutein) were significantly lower in patients with AD compared with controls. In patients with AD, a significant inverse relationship between lymphocyte DNA 8-OHdG content and plasma levels of lycopene, lutein, alpha-carotene, and beta-carotene, respectively, was observed. CONCLUSIONS: Markers of oxidative damage are increased in AD and correlate with decreased levels of plasma antioxidants. These findings suggest that lymphocyte DNA 8-OHdG content in patients with AD reflects a condition of increased oxidative stress related to a poor antioxidant status.
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“In addition, several nonenzymatic antioxidants such as vitamin C, vitamin A, vitamin E, and carotenoids were lower in the plasma of patients with AD compared with controls and are associated to increased levels of oxidative damage markers [155].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [155]
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Cites
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A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
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Oxidative stress and Alzheimer disease
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Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease
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Self-citationOxidative Stress: Introductory Remarks
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Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain
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Self-citationCytochrome oxidase deficiency in Alzheimer’s disease
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The role of antioxidants in the chemistry of oxidative stress: A review
Pisoschi, A. M., & Pop, A. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.04.040 · Cited by 2,963
The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates
Franceschi, C., Garagnani, P., Morsiani, C., Conte, M., Santoro, A., Grignolio, A., Monti, D., Capri, M., & Salvioli, S. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00061 · Cited by 945
Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview
Mariani, E., Polidori, M. C., Cherubini, A., & Mecocci, P. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.04.023 · Cited by 691
Self-citationPlasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease
Rinaldi, P., Polidori, M. C., Metastasio, A., Mariani, E., Mattioli, P., Cherubini, A., Catani, M., Cecchetti, R., Senin, U., & Mecocci, P. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00031-9 · Cited by 571
Self-citationOxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease
Lovell, M. A., & Markesbery, W. R. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm821 · Cited by 515
Metadata
- Authors
- Mecocci, P.
- Affiliations
- University of Perugia (IT)
- Corresponding author
- Mecocci, Patrizia
- ORCID
- Mecocci, Patrizia
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2002-05-01
- Volume
- 59
- Issue
- 5
- Pages
- 794
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2130940521
- Cited by
- 229
- References
- 53
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 11 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 7 · 2013: 15 · 2012: 8
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, oxidative stress, 8-hydroxy-2'-deoxyguanosine, lymphocyte DNA damage, plasma antioxidants, carotenoids, lycopene, lutein, vitamin C, vitamin E, vitamin A, oxidative damage, biomarkers
- MeSH terms
- 8-Hydroxy-2'-Deoxyguanosine, Aged, Aged, 80 and over, Alzheimer Disease, Antioxidants, Deoxyguanosine, DNA Damage, Female, Humans, Lymphocytes, Male, Oxidation-Reduction, Linear Models, Oxidative Stress
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