Initial Evaluations for Multiple Sclerosis in a University Multiple Sclerosis Center: Outcomes and Role of Magnetic Resonance Imaging in Referral
Abstract
Objective To evaluate diagnostic outcomes, especially as they relate to reason for referral, of patients referred to a university-based multiple sclerosis (MS) center for possible MS. Methods Retrospective medical record review of all new patient visits to University of Colorado Multiple Sclerosis Center, Denver, from January 1, 2001, to June 30, 2003. Results Of 281 patients referred to evaluate the possibility of MS, after initial review 33% were diagnosed with MS or possible MS by the McDonald criteria. The rest had other neurological conditions (31.5%), probable psychiatric diagnoses (22.5%), or no clear diagnosis was made (12.5%). Of patients with typical, possible, or atypical demyelinating syndromes, 71%, 27%, and 0%, respectively (P Conclusions A significant percentage of patients referred to a university-based MS center have little or no likelihood of having MS, and many have undiagnosed, untreated psychiatric illness or common conditions with abnormal brain MRI results. With respect to the diagnosis of MS, greater training of primary care professionals, neurologists, and radiologists is necessary.
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In a retrospective review of 281 new patient evaluations at a tertiary MS center in the United States between 2001 and 2003, 63 out of 186 (34%) patients who did not have MS or possible MS had 'possible psychiatric disease'.
“In a retrospective review of 281 new patient evaluations at a tertiary MS center in the United States between 2001 and 2003, 63 out of 186 (34%) patients who did not have MS or possible MS had “possible psychiatric disease” [20].”
From Functional neurological disorder and multiple sclerosis: a systematic review of misdiagnosis and clinical overlap (2022) · cites this paper as [20]
The applicability of the 2010 McDonald Criteria has been reported in patients from Canada, Italy, the Netherlands, Spain, and Russia.
“The applicability of the 2010 McDonald Criteria has been reported in patients from Canada, 17 Italy, 18 the Netherlands, 19 Spain, 20 and Russia. 21”
From Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria (2018) · cites this paper as [17]
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Incidence of multiple sclerosis misdiagnosis in referrals to two academic centers
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- Authors
- Carmosino, M. J., Brousseau, K. M., Arciniegas, D. B., & Corboy, J. R.
- Affiliations
- University of Colorado Anschutz (US)
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2005-04-01
- Volume
- 62
- Issue
- 4
- Pages
- 585
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2150783406
- Cited by
- 74
- References
- 1
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 6 · 2016: 6 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Family Practice › Clinical Reasoning and Diagnostic Skills
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- multiple sclerosis, diagnostic yield, referral patterns, McDonald criteria, demyelinating syndromes, brain MRI abnormalities, psychiatric comorbidity, differential diagnosis, neuroimaging interpretation
- MeSH terms
- Academic Medical Centers, Mental Disorders, Central Nervous System, Central Nervous System Diseases, Colorado, Diagnosis, Differential, Diagnostic Errors, Humans, Magnetic Resonance Imaging, Multiple Sclerosis, Neurologic Examination, Radiography, Referral and Consultation, Retrospective Studies, Outcome Assessment, Health Care
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