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Assessment of β-Amyloid in a Frontal Cortical Brain Biopsy Specimen and by Positron Emission Tomography With Carbon 11–Labeled Pittsburgh Compound B
Abstract
Objective To compare carbon 11-labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) findings in patients with and without Alzheimer disease lesions in frontal cortical biopsy specimens. Design Cross-sectional study of [11C]PiB PET findings in patients with or without beta-amyloid (Abeta) aggregates in frontal cortical biopsy specimens. Setting Two university hospitals in Finland. Patients Ten patients who had undergone intraventricular pressure monitoring with a frontal cortical biopsy (evaluated for Abeta aggregates and hyperphosphorylated tau) for suspected normal-pressure hydrocephalus. Interventions [11C]PiB PET and evaluation for cognitive impairment using a battery of neuropsychological tests. Main outcome measures Immunohistochemical evaluation for Abeta aggregates and hyperphosphorylated tau in the frontal cortical biopsy specimen and [11C]PiB PET. Results In patients with Abeta aggregates in the frontal cortical biopsy specimen, PET imaging revealed higher [11C]PiB uptake (P Conclusions Our study supports the use of noninvasive [11C]PiB PET in the assessment of Abeta deposition in the brain. Large prospective studies are required to verify whether [11C]PiB PET will be a diagnostic aid, particularly in early Alzheimer disease.
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“the [11C]-benzothiazole radiotracer, Pittsburgh Compound B (PIB), as well as other tracers, can bind to fibrillar Aβ plaques, allowing for visualization of brain amyloid in individuals during positron emission tomography (PET) (23-25).”
From Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance (2011) · cites this paper as [25]
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Metadata
- Authors
- Leinonen, V.
- Affiliations
- Kuopio University Hospital (FI)
- Corresponding author
- Leinonen, Ville
- ORCID
- Leinonen, Ville
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2008-10-01
- Volume
- 65
- Issue
- 10
- Pages
- 1304
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2136040838
- Cited by
- 199
- References
- 19
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 15 · 2015: 10 · 2014: 17 · 2013: 17 · 2012: 27
- FWCI
- 16.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- amyloid-beta, 11C-Pittsburgh compound B, positron emission tomography, Alzheimer's disease, amyloid imaging, hyperphosphorylated tau, normal pressure hydrocephalus, cognitive impairment
- MeSH terms
- Aged, Alzheimer Disease, Aniline Compounds, Biopsy, Brain, Brain Mapping, Cross-Sectional Studies, Diagnosis, Differential, Female, Frontal Lobe, Humans, Hydrocephalus, Normal Pressure, Image Processing, Computer-Assisted, Male, Neuropsychological Tests, Predictive Value of Tests, Thiazoles, Amyloid beta-Peptides, Neurofibrillary Tangles, tau Proteins, Disease Progression, Intracranial Hypertension, Early Diagnosis, Positron-Emission Tomography, Plaque, Amyloid
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