Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease
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BACKGROUND: Single-nucleotide polymorphisms (SNPs) in 2 distinct regions of the gene for the sortilin-related receptor (SORL1) (bounded by consecutively numbered SNPs 8-10 and 22-25) were shown to be associated with Alzheimer disease (AD) in multiple ethnically diverse samples. OBJECTIVE: To test the hypothesis that SORL1 is associated with brain magnetic resonance imaging (MRI) measurements of atrophy and/or vascular disease. DESIGN, SETTING, AND PATIENTS: We evaluated the association of 30 SNPs spanning SORL1 with MRI measures of general cerebral atrophy, hippocampal atrophy, white matter hyperintensities, and overall cerebrovascular disease in 44 African American and 182 white sibships from the MIRAGE Study. We performed single- and 3-SNP haplotype association analyses using family-based tests. Haplotypes found to be significantly associated with at least 1 MRI trait were tested for association with 6 pathological traits in a separate sample of 69 white patients with autopsy-confirmed AD. RESULTS: In white patients, white matter hyperintensities were associated with multiple markers in the region encompassing SNPs 6 to 10, whereas cerebral and hippocampal atrophy were associated with markers from the region including SNPs 21 to 26. Examination of specific 3-SNP haplotypes from these 2 regions in the autopsy-confirmed cases of AD revealed association of white matter disease with SNPs 8 to 10 and association of hippocampal atrophy with SNPs 22 to 26. The haplotype CGC at SNPs 8 to 10 was associated with fewer white matter changes in the clinical (P<.001) and autopsy (P=.02) samples. CONCLUSIONS: Variants of SORL1 previously associated with AD are also associated with MRI and neuropathological measures of neurodegenerative and cerebrovascular disease. These findings not only support the hypothesis that multiple areas in SORL1 are of functional importance but also raise the possibility that multiple SORL1 variants influence amyloid precursor protein or endothelial lipoprotein processing or both in different regions of the brain.
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SNPs in and around APOE, BIN1, SORL1, and CR1 have been associated with traits including medial temporal lobe atrophy and cortical thickness.
“SNPs in and around candidate genes including APOE, BIN1, SORL1, and CR1 have been associated with traits including medial temporal lobe atrophy and cortical thickness [225–228]”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [228]
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References 51 · Cited by 61
- Authors
- Cuenco, K. T.
- Affiliations
- Boston University (US)
- Corresponding author
- Cuenco, Karen T.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2008-12-01
- Volume
- 65
- Issue
- 12
- Pages
- 1640
- ISSN
- 0003-9942 (ISSN-L)
- PMC
- PMC2719762
- OpenAlex
- W2162906229
- Cited by
- 61
- References
- 51
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 5 · 2017: 1 · 2016: 7 · 2015: 1 · 2014: 5 · 2013: 8 · 2012: 9
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (081864)
- National Institutes of Health (UL1TR000454, AG13846)
- National Institute on Aging (P30AG010129, R01-HG/AG-02213, K24AG027841, P30AG013846, R01AG009029, R01 AG09029, P30-AG13846))
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- SORL1, Alzheimer's disease, single nucleotide polymorphisms, haplotype association, brain atrophy, hippocampal atrophy, white matter hyperintensities, cerebrovascular disease, neurodegeneration, genetic susceptibility, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cerebrovascular Disorders, Female, Genotype, Humans, Magnetic Resonance Imaging, Male, Models, Biological, Nerve Degeneration, Neuropsychological Tests, Polymorphism, Genetic, Genetic Predisposition to Disease, LDL-Receptor Related Proteins, Membrane Transport Proteins
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