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Central Pontine Myelinolysis: A Hitherto Undescribed Disease Occurring in Alcoholic and Malnourished Patients
Abstract
In the course of our studies of the neuropathology of alcoholism, which were begun at the Neurological Unit, Boston City Hospital, and have continued in the laboratories of the Neurology Service, Massachusetts General Hospital, two of us (R. D. A. and M. V.) observed three, perhaps four, cases in which the myelin sheaths of all the nerve fibers in the central part of the basis pontis had been destroyed in a single, large, symmetric focus. The nerve cells and axis cylinders were spared for the most part, and the blood vessels were patent and unaffected. There were no signs of inflammation in or near the lesion. The disease had occurred on a background of alcoholism and malnutrition; in the two cases with the largest lesions, it had manifested itself clinically by a pseudobulbar palsy and quadriplegia, leading to death in about 13 and 26 days. In the other two cases
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Cited by
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Sheng, M., Zhang, M., & Lu, W. (2026) · BMC Pediatrics · doi:10.1186/s12887-026-07049-1
Metadata
- Authors
- ADAMS, R. D.
- Venue
- A.M.A. Archives of Neurology & Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1959-02-01
- Volume
- 81
- Issue
- 2
- Pages
- 154
- ISSN
- 0096-6886 (ISSN-L)
- OpenAlex
- W4294349871
- Cited by
- 621
- References
- 0
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Central Pontine Myelinolysis: A Hitherto Undescribed Disease Occurring in Alcoholic and Malnourished Patients. https://app.cochat.ai/papers/10.1001/archneurpsyc.1959.02340140020004
- The paper
- ADAMS, R. D. (1959). Central Pontine Myelinolysis: A Hitherto Undescribed Disease Occurring in Alcoholic and Malnourished Patients. A.M.A. Archives of Neurology & Psychiatry. https://doi.org/10.1001/archneurpsyc.1959.02340140020004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
