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CATARACT FOLLOWING DI-NITROPHENOL TREATMENT FOR OBESITY
Abstract
An excellent review of the subject of di-nitrophenol in general was given in a report by the Council on Pharmacy and Chemistry of the American Medical Association,1from which I shall quote freely. The actions of certain nitro derivatives of phenol and naphthol as accelerators of metabolism have been studied for the past fifty years. Cazeneuve and Lepine2in 1885 described the increase in the metabolism of dogs given di-nitronaphthol. A few years later Gibbs and Reichert3reported similar observations with the use of di-nitrophenol. During the war many cases of di-nitrophenol poisoning were observed among French munition workers. The poisoning, which was often severe and sometimes fatal, occurred so frequently that special pharmacologic study was instituted. The findings were reported on by Magne, Mayer and Plantefol4in France and by Perkins5in America. In 1933 Tainter and Cutting1and their coinvestigators, proceeding independently,
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Reported side effects of DNP include acute cataract, sensory axonal polyneuropathy, fever, tachycardia, sweating, nausea, rash, breathing difficulties, abdominal pain, agitation, headache, and death.
“The reported side effects of DNP include acute cataract [261,262], sensory axonal polyneuropathy [263], fever, tachycardia, sweating, nausea, rash, breathing difficulties, abdominal pain, agitation, headache, and death [264,265].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [262]
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References 14 · Cited by 21
Metadata
- Authors
- HORNER, W. D.
- Corresponding author
- HORNER, W. D.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1936-09-01
- Volume
- 16
- Issue
- 3
- Pages
- 447-461
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W1993152627
- Cited by
- 21
- References
- 14
- Citations by year
- 2024: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2014: 1
- FWCI
- 16.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Ophthalmology (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Ophthalmology › Intraocular Surgery and Lenses
- Keywords
- cataract, obesity, weight loss, adverse drug reactions
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