Cited by 21Drug-Induced Ocular ToxicityPharmacology and Obesity TreatmentIntraocular Surgery and Lenses

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CATARACT FOLLOWING DI-NITROPHENOL TREATMENT FOR OBESITY

HORNER, W. D.·1936·Archives of Ophthalmology

Abstract

An excellent review of the subject of di-nitrophenol in general was given in a report by the Council on Pharmacy and Chemistry of the American Medical Association,1from which I shall quote freely. The actions of certain nitro derivatives of phenol and naphthol as accelerators of metabolism have been studied for the past fifty years. Cazeneuve and Lepine2in 1885 described the increase in the metabolism of dogs given di-nitronaphthol. A few years later Gibbs and Reichert3reported similar observations with the use of di-nitrophenol. During the war many cases of di-nitrophenol poisoning were observed among French munition workers. The poisoning, which was often severe and sometimes fatal, occurred so frequently that special pharmacologic study was instituted. The findings were reported on by Magne, Mayer and Plantefol4in France and by Perkins5in America. In 1933 Tainter and Cutting1and their coinvestigators, proceeding independently,

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Crossref · 10.1001/archopht.1936.00840210121009

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  • Reported side effects of DNP include acute cataract, sensory axonal polyneuropathy, fever, tachycardia, sweating, nausea, rash, breathing difficulties, abdominal pain, agitation, headache, and death.

    “The reported side effects of DNP include acute cataract [261,262], sensory axonal polyneuropathy [263], fever, tachycardia, sweating, nausea, rash, breathing difficulties, abdominal pain, agitation, headache, and death [264,265].”

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References 14 · Cited by 21

Metadata

Authors
HORNER, W. D.
Corresponding author
HORNER, W. D.
Venue
Archives of Ophthalmology
Published
1936-09-01
Volume
16
Issue
3
Pages
447-461
ISSN
0003-9950 (ISSN-L)
OpenAlex
W1993152627
Cited by
21
References
14
Citations by year
2024: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2014: 1
FWCI
16.55
Type
journal article
Language
en
Open access
closed
Locations
Archives of Ophthalmology (publishedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
  • Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
  • Health Sciences › Medicine › Ophthalmology › Intraocular Surgery and Lenses
Keywords
cataract, obesity, weight loss, adverse drug reactions

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