Immunoglobulins in the Human Eye: Location, Type, and Amount
Abstract
Immunoglobulins were found in all structures of the eye except the lens. The highest concentrations (up to one-half the amount in serum) were found in the cornea, choroid, and conjunctiva. Moderate concentrations were found in the muscle and sclera. Low concentrations (less than 5% of the serum level) were found in the ciliary body, iris, aqueous, and retina. All five immunoglobulins and albumin were present in the immunoglobulin-containing tissues except for the cornea, which did not routinely contain IgM.
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Antibodies have been shown to be capable of mediating ocular pathology in multiple contexts.
“All eye tissues except for the lens contain antibodies, and antibodies have been shown to be capable of mediating ocular pathology in multiple contexts21–25.”
From Investigation of Cas9 Antibodies in the Human Eye (2022) · cites this paper as [21]
Human vitreous fluid is thought to contain approximately 100-fold fewer antibodies than serum.
“Human vitreous fluid is thought to contain approximately 100-fold fewer antibodies than serum and it is unknown whether α-Cas9 is represented21,33.”
From Investigation of Cas9 Antibodies in the Human Eye (2022) · cites this paper as [21]
All eye tissues except the lens contain antibodies.
“All eye tissues except for the lens contain antibodies, and antibodies have been shown to be capable of mediating ocular pathology in multiple contexts21–25.”
From Investigation of Cas9 Antibodies in the Human Eye (2022) · cites this paper as [21]
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References 13 · Cited by 103
- Authors
- Allansmith, M. R.
- Corresponding author
- Allansmith, Mathea R.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1973-01-01
- Volume
- 89
- Issue
- 1
- Pages
- 36
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W1983026833
- Cited by
- 103
- References
- 13
- Citations by year
- 2026: 1 · 2025: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 2 · 2014: 1
- FWCI
- 13.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Keywords
- immunoglobulins, eye, cornea, choroid, conjunctiva, sclera, ciliary body, iris, aqueous humor, retina, IgM, serum immunoglobulin levels, ocular tissues
- MeSH terms
- Adult, Aged, Albumins, Basement Membrane, Choroid, Ciliary Body, Conjunctiva, Cornea, Endothelium, Epithelium, Eye, Female, Fluorescent Antibody Technique, Immunodiffusion, Humans, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Immunoglobulins, Iris, Lens, Crystalline, Male, Middle Aged, Oculomotor Muscles
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