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Cited by 229Retinal Diseases and TreatmentsRetinal and Macular SurgeryOcular Diseases and Behçet’s Syndrome

The DOI matches its Crossref record.

Argon Laser Photocoagulation for Neovascular Maculopathy: Three-Year Results From Randomized Clinical Trials

·1986·Archives of Ophthalmology
DOI 10.1001/archopht.1986.01050170084028
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Abstract

• The Macular Photocoagulation Study randomized controlled clinical trials designed to determine whether argon laser photocoagulation is effective for preventing or delaying severe visual loss in eyes with an extrafoveal choroidal neovascular membrane secondary to senile macular degeneration (Senile Macular Degeneration Study [SMDS]), ocular histoplasmosis (Ocular Histoplasmosis Study [OHS]), or idiopathic neovascularization (Idiopathic Neovascularization Study [INVS]). Eligible patients were assigned randomly to a "treatment" group or to a "no treatment" group until recruitment was terminated in 1982 (SMDS) and 1983 (OHS and INVS) because of demonstrated short-term treatment benefit. As of Aug 31, 1985, three or more years of scheduled follow-up examinations had been completed for 208 (88%) of 236 eyes in the SMDS, 203 (77%) of 262 eyes in the OHS, and 51 (76%) of 67 eyes in the INVS. The relative risk of experiencing severe loss of vision after three years in eyes initially assigned to the no treatment group in comparison with eyes assigned to the argon laser photocoagulation group was 1.4 in the SMDS (95% confidence interval [CI]: 1.1 to 1.9), 5.5 in the OHS (95% CI: 3.9 to 10.8), and 2.3 in the INVS (95% CI: 0.8 to 6.5). The beneficial effects of argon laser treatment have persisted in all three studies in spite of the fact that some eyes in the "no treatment" groups were treated later in their clinical course as a result of the evidence of early benefit. Follow-up of all patients continues so that treatment effectiveness over a five-year period can be assessed.

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Metadata

Venue
Archives of Ophthalmology
Publisher
American Medical Association (AMA)
Published
1986-05-01
Volume
104
Issue
5
Pages
694
ISSN
0003-9950 (ISSN-L)
DOI
10.1001/archopht.1986.01050170084028
OpenAlex
W4243337108
Cited by
227
References
0
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 14
FWCI
9.32
Type
journal article
Language
en
Open access
closed
Locations
Archives of Ophthalmology (publishedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Ophthalmology › Retinal and Macular Surgery
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
argon laser photocoagulation, choroidal neovascularization, senile macular degeneration, ocular histoplasmosis, macular photocoagulation, blindness prevention, long-term treatment effectiveness

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