Granulomatous reaction to Bruch's membrane in age-related macular degeneration
Abstract
The histopathologic features of a granulomatous reaction in one eye of a patient with neovascular age-related macular degeneration are presented. Multiple multinucleated giant cells were found in intimate association with Bruch's membrane and at the margin of Bruch's membrane defects. Multinucleated giant cells appear to participate in the breakdown of Bruch's membrane and, together with diffuse disease of the retinal pigment epithelium and changes in the physicochemical properties of Bruch's membrane, may provide angiogenic stimulus for choroidal neovascularization in age-related macular degeneration.
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Macrophages have been documented both morphologically and functionally in neovascular age-related macular degeneration.
“Macrophages have been documented both morphologically and functionally in neovascular age-related macular degeneration.137–142”
From Age-related macular degeneration (2008) · cites this paper as [139]
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References 39 · Cited by 162
- Authors
- Dastgheib, K.
- Corresponding author
- Dastgheib, Kourosh
- ORCID
- Dastgheib, Kourosh
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1994-06-01
- Volume
- 112
- Issue
- 6
- Pages
- 813
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W2034347345
- Cited by
- 162
- References
- 39
- Citations by year
- 2025: 3 · 2024: 5 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 8
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- granulomatous inflammation, Bruch's membrane, age-related macular degeneration, neovascular age-related macular degeneration, multinucleated giant cells, retinal pigment epithelium, choroidal neovascularization, angiogenesis, histopathology
- MeSH terms
- Aged, Aged, 80 and over, Choroid, Granuloma, Giant Cell, Humans, Macular Degeneration, Male, Neovascularization, Pathologic, Retinal Diseases, Bruch Membrane
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